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Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, Keck GE. Kedei N, et al. Among authors: garfield sh. ACS Chem Biol. 2013 Apr 19;8(4):767-77. doi: 10.1021/cb300671s. Epub 2013 Feb 1. ACS Chem Biol. 2013. PMID: 23369356 Free PMC article.
The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.
Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, Blumberg PM. Kedei N, et al. Among authors: garfield sh. Biochem Pharmacol. 2011 Jun 1;81(11):1296-308. doi: 10.1016/j.bcp.2011.03.018. Epub 2011 Mar 30. Biochem Pharmacol. 2011. PMID: 21458422 Free PMC article.
A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.
Pu Y, Perry NA, Yang D, Lewin NE, Kedei N, Braun DC, Choi SH, Blumberg PM, Garfield SH, Stone JC, Duan D, Marquez VE. Pu Y, et al. Among authors: garfield sh. J Biol Chem. 2005 Jul 22;280(29):27329-38. doi: 10.1074/jbc.M414132200. Epub 2005 May 27. J Biol Chem. 2005. PMID: 15923197 Free article.
75 results