Brown JH - Search Results

1

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM. Pereira L, et al. Among authors: brown jh. Circulation. 2013 Feb 26;127(8):913-22. doi: 10.1161/CIRCULATIONAHA.12.148619. Epub 2013 Jan 30. Circulation. 2013. PMID: 23363625 Free PMC article.

2

Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.

Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH. Ling H, et al. Among authors: brown jh. J Clin Invest. 2009 May;119(5):1230-40. doi: 10.1172/JCI38022. Epub 2009 Apr 20. J Clin Invest. 2009. PMID: 19381018 Free PMC article.

3

Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice.

Zhang T, Guo T, Mishra S, Dalton ND, Kranias EG, Peterson KL, Bers DM, Brown JH. Zhang T, et al. Among authors: brown jh. Circ Res. 2010 Feb 5;106(2):354-62. doi: 10.1161/CIRCRESAHA.109.207423. Epub 2009 Dec 3. Circ Res. 2010. PMID: 19959778 Free PMC article.

4

Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes.

Mishra S, Gray CB, Miyamoto S, Bers DM, Brown JH. Mishra S, et al. Among authors: brown jh. Circ Res. 2011 Dec 9;109(12):1354-62. doi: 10.1161/CIRCRESAHA.111.248401. Epub 2011 Oct 13. Circ Res. 2011. PMID: 21998325 Free PMC article.

5

CaMKIIδ mediates β-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic β-adrenergic stimulation.

Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH. Grimm M, et al. Among authors: brown jh. J Mol Cell Cardiol. 2015 Aug;85:282-91. doi: 10.1016/j.yjmcc.2015.06.007. Epub 2015 Jun 14. J Mol Cell Cardiol. 2015. PMID: 26080362 Free PMC article.

6

CaMKIIδC Drives Early Adaptive Ca²⁺ Change and Late Eccentric Cardiac Hypertrophy.

Ljubojevic-Holzer S, Herren AW, Djalinac N, Voglhuber J, Morotti S, Holzer M, Wood BM, Abdellatif M, Matzer I, Sacherer M, Radulovic S, Wallner M, Ivanov M, Wagner S, Sossalla S, von Lewinski D, Pieske B, Brown JH, Sedej S, Bossuyt J, Bers DM. Ljubojevic-Holzer S, et al. Among authors: brown jh. Circ Res. 2020 Oct 9;127(9):1159-1178. doi: 10.1161/CIRCRESAHA.120.316947. Epub 2020 Aug 21. Circ Res. 2020. PMID: 32821022 Free PMC article.

7

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release.

Maier LS, Zhang T, Chen L, DeSantiago J, Brown JH, Bers DM. Maier LS, et al. Among authors: brown jh. Circ Res. 2003 May 2;92(8):904-11. doi: 10.1161/01.RES.0000069685.20258.F1. Epub 2003 Apr 3. Circ Res. 2003. PMID: 12676813

8

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure.

Zhang T, Maier LS, Dalton ND, Miyamoto S, Ross J Jr, Bers DM, Brown JH. Zhang T, et al. Among authors: brown jh. Circ Res. 2003 May 2;92(8):912-9. doi: 10.1161/01.RES.0000069686.31472.C5. Epub 2003 Apr 3. Circ Res. 2003. PMID: 12676814

9

Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes.

Kohlhaas M, Zhang T, Seidler T, Zibrova D, Dybkova N, Steen A, Wagner S, Chen L, Brown JH, Bers DM, Maier LS. Kohlhaas M, et al. Among authors: brown jh. Circ Res. 2006 Feb 3;98(2):235-44. doi: 10.1161/01.RES.0000200739.90811.9f. Epub 2005 Dec 22. Circ Res. 2006. PMID: 16373600

10

CaMKIIδC slows [Ca]i decline in cardiac myocytes by promoting Ca sparks.

Guo T, Zhang T, Ginsburg KS, Mishra S, Brown JH, Bers DM. Guo T, et al. Among authors: brown jh. Biophys J. 2012 Jun 6;102(11):2461-70. doi: 10.1016/j.bpj.2012.04.015. Epub 2012 Jun 5. Biophys J. 2012. PMID: 22713561 Free PMC article.

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