Horwich AL - Search Results

1

Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration.

Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M. Bilguvar K, et al. Among authors: horwich al. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3489-94. doi: 10.1073/pnas.1222732110. Epub 2013 Jan 28. Proc Natl Acad Sci U S A. 2013. PMID: 23359680 Free PMC article.

2

GroEL/GroES cycling: ATP binds to an open ring before substrate protein favoring protein binding and production of the native state.

Tyagi NK, Fenton WA, Horwich AL. Tyagi NK, et al. Among authors: horwich al. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20264-9. doi: 10.1073/pnas.0911556106. Epub 2009 Nov 13. Proc Natl Acad Sci U S A. 2009. PMID: 19915138 Free PMC article.

3

ATP-triggered ADP release from the asymmetric chaperonin GroEL/GroES/ADP7 is not the rate-limiting step of the GroEL/GroES reaction cycle.

Tyagi NK, Fenton WA, Horwich AL. Tyagi NK, et al. Among authors: horwich al. FEBS Lett. 2010 Mar 5;584(5):951-3. doi: 10.1016/j.febslet.2010.01.021. Epub 2010 Jan 17. FEBS Lett. 2010. PMID: 20083109 Free PMC article.

4

Hsp110 mitigates α-synuclein pathology in vivo.

Taguchi YV, Gorenberg EL, Nagy M, Thrasher D, Fenton WA, Volpicelli-Daley L, Horwich AL, Chandra SS. Taguchi YV, et al. Among authors: horwich al. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24310-24316. doi: 10.1073/pnas.1903268116. Epub 2019 Nov 4. Proc Natl Acad Sci U S A. 2019. PMID: 31685606 Free PMC article.

5

Double mutant MBP refolds at same rate in free solution as inside the GroEL/GroES chaperonin chamber when aggregation in free solution is prevented.

Tyagi NK, Fenton WA, Deniz AA, Horwich AL. Tyagi NK, et al. Among authors: horwich al. FEBS Lett. 2011 Jun 23;585(12):1969-72. doi: 10.1016/j.febslet.2011.05.031. Epub 2011 May 20. FEBS Lett. 2011. PMID: 21609718 Free PMC article.

6

Molecular chaperone Hsp110 rescues a vesicle transport defect produced by an ALS-associated mutant SOD1 protein in squid axoplasm.

Song Y, Nagy M, Ni W, Tyagi NK, Fenton WA, López-Giráldez F, Overton JD, Horwich AL, Brady ST. Song Y, et al. Among authors: horwich al. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5428-33. doi: 10.1073/pnas.1303279110. Epub 2013 Mar 18. Proc Natl Acad Sci U S A. 2013. PMID: 23509252 Free PMC article.

7

RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse.

Bandyopadhyay U, Cotney J, Nagy M, Oh S, Leng J, Mahajan M, Mane S, Fenton WA, Noonan JP, Horwich AL. Bandyopadhyay U, et al. Among authors: horwich al. PLoS One. 2013;8(1):e53575. doi: 10.1371/journal.pone.0053575. Epub 2013 Jan 3. PLoS One. 2013. PMID: 23301088 Free PMC article.

8

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.

Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR 3rd, Perrin S, Feany MB, Horwich AL. Wang J, et al. Among authors: horwich al. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1392-7. doi: 10.1073/pnas.0813045106. Epub 2009 Jan 26. Proc Natl Acad Sci U S A. 2009. PMID: 19171884 Free PMC article.

9

Disulfide formation as a probe of folding in GroEL-GroES reveals correct formation of long-range bonds and editing of incorrect short-range ones.

Park ES, Fenton WA, Horwich AL. Park ES, et al. Among authors: horwich al. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2145-50. doi: 10.1073/pnas.0610989104. Epub 2007 Feb 5. Proc Natl Acad Sci U S A. 2007. PMID: 17283341 Free PMC article.

10

Perturbed ATPase activity and not "close confinement" of substrate in the cis cavity affects rates of folding by tail-multiplied GroEL.

Farr GW, Fenton WA, Horwich AL. Farr GW, et al. Among authors: horwich al. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5342-7. doi: 10.1073/pnas.0700820104. Epub 2007 Mar 19. Proc Natl Acad Sci U S A. 2007. PMID: 17372195 Free PMC article.

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