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Page 1
The inhibin B response in male rats treated with two drug candidates.
Chapin RE, Alvey JD, Goldstein RA, Dokmanovich MG, Reagan WJ, Johnson K, Geoly FJ. Chapin RE, et al. Among authors: geoly fj. Birth Defects Res B Dev Reprod Toxicol. 2013 Feb;98(1):54-62. doi: 10.1002/bdrb.21040. Epub 2013 Jan 24. Birth Defects Res B Dev Reprod Toxicol. 2013. PMID: 23348891
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Esler WP, Tesz GJ, Hellerstein MK, Beysen C, Sivamani R, Turner SM, Watkins SM, Amor PA, Carvajal-Gonzalez S, Geoly FJ, Biddle KE, Purkal JJ, Fitch M, Buckeridge C, Silvia AM, Griffith DA, Gorgoglione M, Hassoun L, Bosanac SS, Vera NB, Rolph TP, Pfefferkorn JA, Sonnenberg GE. Esler WP, et al. Among authors: geoly fj. Sci Transl Med. 2019 May 15;11(492):eaau8465. doi: 10.1126/scitranslmed.aau8465. Sci Transl Med. 2019. PMID: 31092695 Clinical Trial.
BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Bollinger E, Peloquin M, Libera J, Albuquerque B, Pashos E, Shipstone A, Hadjipanayis A, Sun Z, Xing G, Clasquin M, Stansfield JC, Tierney B, Gernhardt S, Siddall CP, Greizer T, Geoly FJ, Vargas SR, Gao LC, Williams G, Marshall M, Rosado A, Steppan C, Filipski KJ, Zhang BB, Miller RA, Roth Flach RJ. Bollinger E, et al. Among authors: geoly fj. Mol Metab. 2022 Dec;66:101611. doi: 10.1016/j.molmet.2022.101611. Epub 2022 Oct 8. Mol Metab. 2022. PMID: 36220546 Free PMC article.
Scientific and Regulatory Policy Committee Points to Consider: Review of the United States Food and Drug Administration (FDA) Guidance on Pathology Peer Review in Nonclinical Toxicology Studies.
McDorman KS, Bennet BM, Colman K, Fikes JD, Keirstead ND, Lanning Retired L, Munch B, Romeike A, Schafer KA, Schorsch F, Thibodeau MS, Thomas HC, Troth S, Vahle JL, Geoly FJ. McDorman KS, et al. Among authors: geoly fj. Toxicol Pathol. 2024 Feb;52(2-3):138-148. doi: 10.1177/01926233241248654. Epub 2024 Jun 6. Toxicol Pathol. 2024. PMID: 38840532 Review.
18 results