Loh C - Search Results

1

Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1.

Bellet MM, Nakahata Y, Boudjelal M, Watts E, Mossakowska DE, Edwards KA, Cervantes M, Astarita G, Loh C, Ellis JL, Vlasuk GP, Sassone-Corsi P. Bellet MM, et al. Among authors: loh c. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3333-8. doi: 10.1073/pnas.1214266110. Epub 2013 Jan 22. Proc Natl Acad Sci U S A. 2013. PMID: 23341587 Free PMC article.

2

SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.

Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, Leung S, Zhong Z, Zhao H, Sweitzer S, Considine T, Riera T, Suri V, White B, Ellis JL, Vlasuk GP, Loh C. Yang H, et al. Among authors: loh c. PLoS One. 2012;7(9):e46364. doi: 10.1371/journal.pone.0046364. Epub 2012 Sep 28. PLoS One. 2012. PMID: 23029496 Free PMC article.

3

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism.

Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA. Hubbard BP, et al. Among authors: loh c. Cell Cycle. 2013 Jul 15;12(14):2233-40. doi: 10.4161/cc.25268. Cell Cycle. 2013. PMID: 23892437 Free PMC article.

4

SIRT1 modulation as a novel approach to the treatment of diseases of aging.

Blum CA, Ellis JL, Loh C, Ng PY, Perni RB, Stein RL. Blum CA, et al. Among authors: loh c. J Med Chem. 2011 Jan 27;54(2):417-32. doi: 10.1021/jm100861p. Epub 2010 Nov 16. J Med Chem. 2011. PMID: 21080630 Review. No abstract available.

5

Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology.

Robers MB, Loh C, Carlson CB, Yang H, Frey EA, Hermanson SB, Bi K. Robers MB, et al. Among authors: loh c. Mol Biosyst. 2011 Jan;7(1):59-66. doi: 10.1039/c0mb00026d. Epub 2010 Oct 8. Mol Biosyst. 2011. PMID: 20931131

6

The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.

Cheng H, Hoffman J, Le P, Nair SK, Cripps S, Matthews J, Smith C, Yang M, Kupchinsky S, Dress K, Edwards M, Cole B, Walters E, Loh C, Ermolieff J, Fanjul A, Bhat GB, Herrera J, Pauly T, Hosea N, Paderes G, Rejto P. Cheng H, et al. Among authors: loh c. Bioorg Med Chem Lett. 2010 May 1;20(9):2897-902. doi: 10.1016/j.bmcl.2010.03.032. Epub 2010 Mar 10. Bioorg Med Chem Lett. 2010. PMID: 20363126

7

Small molecule mediated inhibition of RORγ-dependent gene expression and autoimmune disease pathology in vivo.

Banerjee D, Zhao L, Wu L, Palanichamy A, Ergun A, Peng L, Quigley C, Hamann S, Dunstan R, Cullen P, Allaire N, Guertin K, Wang T, Chao J, Loh C, Fontenot JD. Banerjee D, et al. Among authors: loh c. Immunology. 2016 Apr;147(4):399-413. doi: 10.1111/imm.12570. Epub 2016 Jan 26. Immunology. 2016. PMID: 26694902 Free PMC article.

8

Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: alleviating hERG interactions through structure based design.

Patel SD, Habeski WM, Cheng AC, de la Cruz E, Loh C, Kablaoui NM. Patel SD, et al. Among authors: loh c. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3339-43. doi: 10.1016/j.bmcl.2009.04.006. Epub 2009 Apr 9. Bioorg Med Chem Lett. 2009. PMID: 19435660

9

CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling.

Henry KL, Kellner D, Bajrami B, Anderson JE, Beyna M, Bhisetti G, Cameron T, Capacci AG, Bertolotti-Ciarlet A, Feng J, Gao B, Hopkins B, Jenkins T, Li K, May-Dracka T, Murugan P, Wei R, Zeng W, Allaire N, Buckler A, Loh C, Juhasz P, Lucas B, Ennis KA, Vollman E, Cahir-McFarland E, Hett EC, Ols ML. Henry KL, et al. Among authors: loh c. Sci Signal. 2018 Jul 31;11(541):eaam8216. doi: 10.1126/scisignal.aam8216. Sci Signal. 2018. PMID: 30065029

10

microRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes.

Blevins R, Bruno L, Carroll T, Elliott J, Marcais A, Loh C, Hertweck A, Krek A, Rajewsky N, Chen CZ, Fisher AG, Merkenschlager M. Blevins R, et al. Among authors: loh c. PLoS Genet. 2015 Feb 25;11(2):e1005020. doi: 10.1371/journal.pgen.1005020. eCollection 2015. PLoS Genet. 2015. PMID: 25714103 Free PMC article.

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