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Page 1
Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans.
Sevastianova K, Kotronen A, Gastaldelli A, Perttilä J, Hakkarainen A, Lundbom J, Suojanen L, Orho-Melander M, Lundbom N, Ferrannini E, Rissanen A, Olkkonen VM, Yki-Järvinen H. Sevastianova K, et al. Among authors: perttila j. Am J Clin Nutr. 2011 Jul;94(1):104-11. doi: 10.3945/ajcn.111.012369. Epub 2011 Apr 27. Am J Clin Nutr. 2011. PMID: 21525193 Free article. Clinical Trial.
The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue.
Qadri S, Lallukka-Brück S, Luukkonen PK, Zhou Y, Gastaldelli A, Orho-Melander M, Sammalkorpi H, Juuti A, Penttilä AK, Perttilä J, Hakkarainen A, Lehtimäki TE, Orešič M, Hyötyläinen T, Hodson L, Olkkonen VM, Yki-Järvinen H. Qadri S, et al. Among authors: perttila j. Liver Int. 2020 Sep;40(9):2128-2138. doi: 10.1111/liv.14507. Epub 2020 May 18. Liver Int. 2020. PMID: 32386450
Comparison of dorsocervical with abdominal subcutaneous adipose tissue in patients with and without antiretroviral therapy-associated lipodystrophy.
Sevastianova K, Sutinen J, Greco D, Sievers M, Salmenkivi K, Perttilä J, Olkkonen VM, Wågsäter D, Lidell ME, Enerbäck S, Eriksson P, Walker UA, Auvinen P, Ristola M, Yki-Järvinen H. Sevastianova K, et al. Among authors: perttila j. Diabetes. 2011 Jul;60(7):1894-900. doi: 10.2337/db11-0075. Epub 2011 May 20. Diabetes. 2011. PMID: 21602514 Free PMC article.
PNPLA3 mediates hepatocyte triacylglycerol remodeling.
Ruhanen H, Perttilä J, Hölttä-Vuori M, Zhou Y, Yki-Järvinen H, Ikonen E, Käkelä R, Olkkonen VM. Ruhanen H, et al. Among authors: perttila j. J Lipid Res. 2014 Apr;55(4):739-46. doi: 10.1194/jlr.M046607. Epub 2014 Feb 7. J Lipid Res. 2014. PMID: 24511104 Free PMC article.
Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease.
Soronen J, Yki-Järvinen H, Zhou Y, Sädevirta S, Sarin AP, Leivonen M, Sevastianova K, Perttilä J, Laurila PP, Sigruener A, Schmitz G, Olkkonen VM. Soronen J, et al. Among authors: perttila j. Physiol Rep. 2016 Jan;4(1):e12661. doi: 10.14814/phy2.12661. Physiol Rep. 2016. PMID: 26733244 Free PMC article.
Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease.
Westerbacka J, Kotronen A, Fielding BA, Wahren J, Hodson L, Perttilä J, Seppänen-Laakso T, Suortti T, Arola J, Hultcrantz R, Castillo S, Olkkonen VM, Frayn KN, Orešič M, Yki-Järvinen H. Westerbacka J, et al. Among authors: perttila j. Gastroenterology. 2010 Dec;139(6):1961-1971.e1. doi: 10.1053/j.gastro.2010.06.064. Epub 2010 Jun 27. Gastroenterology. 2010. PMID: 20600015 Clinical Trial.
Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin.
Nidhina Haridas PA, Soronen J, Sädevirta S, Mysore R, Quagliarini F, Pasternack A, Metso J, Perttilä J, Leivonen M, Smas CM, Fischer-Posovszky P, Wabitsch M, Ehnholm C, Ritvos O, Jauhiainen M, Olkkonen VM, Yki-Järvinen H. Nidhina Haridas PA, et al. Among authors: perttila j. J Clin Endocrinol Metab. 2015 Oct;100(10):E1299-307. doi: 10.1210/jc.2015-1254. Epub 2015 Jul 23. J Clin Endocrinol Metab. 2015. PMID: 26204133
USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.
Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M. Laurila PP, et al. Among authors: perttila j. Sci Transl Med. 2016 Jan 27;8(323):323ra13. doi: 10.1126/scitranslmed.aad0015. Sci Transl Med. 2016. PMID: 26819196
76 results