Wellen KE - Search Results

1

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.

Jiang P, Du W, Mancuso A, Wellen KE, Yang X. Jiang P, et al. Among authors: wellen ke. Nature. 2013 Jan 31;493(7434):689-93. doi: 10.1038/nature11776. Epub 2013 Jan 13. Nature. 2013. PMID: 23334421 Free PMC article.

2

Therapeutic targeting of ACLY in T-ALL in vivo.

da Silva-Diz V, Singh A, Aleksandrova M, Kim O, Thai C, Lancho O, Nunes PR, Affronti H, Su X, Wellen KE, Herranz D. da Silva-Diz V, et al. Among authors: wellen ke. bioRxiv [Preprint]. 2024 Jun 20:2023.03.27.534395. doi: 10.1101/2023.03.27.534395. bioRxiv. 2024. PMID: 37034581 Free PMC article. Preprint.

3

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.

Wellen KE, Lu C, Mancuso A, Lemons JM, Ryczko M, Dennis JW, Rabinowitz JD, Coller HA, Thompson CB. Wellen KE, et al. Genes Dev. 2010 Dec 15;24(24):2784-99. doi: 10.1101/gad.1985910. Epub 2010 Nov 24. Genes Dev. 2010. PMID: 21106670 Free PMC article.

4

IDH mutation impairs histone demethylation and results in a block to cell differentiation.

Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. Lu C, et al. Among authors: wellen ke. Nature. 2012 Feb 15;483(7390):474-8. doi: 10.1038/nature10860. Nature. 2012. PMID: 22343901 Free PMC article.

5

A two-way street: reciprocal regulation of metabolism and signalling.

Wellen KE, Thompson CB. Wellen KE, et al. Nat Rev Mol Cell Biol. 2012 Mar 7;13(4):270-6. doi: 10.1038/nrm3305. Nat Rev Mol Cell Biol. 2012. PMID: 22395772 Review.

6

ATM couples replication stress and metabolic reprogramming during cellular senescence.

Aird KM, Worth AJ, Snyder NW, Lee JV, Sivanand S, Liu Q, Blair IA, Wellen KE, Zhang R. Aird KM, et al. Among authors: wellen ke. Cell Rep. 2015 May 12;11(6):893-901. doi: 10.1016/j.celrep.2015.04.014. Epub 2015 Apr 30. Cell Rep. 2015. PMID: 25937285 Free PMC article.

7

Molecular biology: Salvaging the genome.

Sivanand S, Wellen KE. Sivanand S, et al. Among authors: wellen ke. Nature. 2015 Aug 6;524(7563):40-1. doi: 10.1038/nature14638. Epub 2015 Jul 22. Nature. 2015. PMID: 26200344 No abstract available.

8

Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage.

Liu L, Shah S, Fan J, Park JO, Wellen KE, Rabinowitz JD. Liu L, et al. Among authors: wellen ke. Nat Chem Biol. 2016 May;12(5):345-52. doi: 10.1038/nchembio.2047. Epub 2016 Mar 21. Nat Chem Biol. 2016. PMID: 26999781 Free PMC article.

9

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.

Shah S, Carriveau WJ, Li J, Campbell SL, Kopinski PK, Lim HW, Daurio N, Trefely S, Won KJ, Wallace DC, Koumenis C, Mancuso A, Wellen KE. Shah S, et al. Among authors: wellen ke. Oncotarget. 2016 Jul 12;7(28):43713-43730. doi: 10.18632/oncotarget.9666. Oncotarget. 2016. PMID: 27248322 Free PMC article.

10

Metabolic control of epigenetics in cancer.

Kinnaird A, Zhao S, Wellen KE, Michelakis ED. Kinnaird A, et al. Among authors: wellen ke. Nat Rev Cancer. 2016 Nov;16(11):694-707. doi: 10.1038/nrc.2016.82. Epub 2016 Sep 16. Nat Rev Cancer. 2016. PMID: 27634449 Review.

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