Schwans JP - Search Results

1

Ground state destabilization from a positioned general base in the ketosteroid isomerase active site.

Ruben EA, Schwans JP, Sonnett M, Natarajan A, Gonzalez A, Tsai Y, Herschlag D. Ruben EA, et al. Among authors: schwans jp. Biochemistry. 2013 Feb 12;52(6):1074-81. doi: 10.1021/bi301348x. Epub 2013 Jan 30. Biochemistry. 2013. PMID: 23311398 Free PMC article.

2

Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.

Schwans JP, Kraut DA, Herschlag D. Schwans JP, et al. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14271-5. doi: 10.1073/pnas.0901032106. Epub 2009 Aug 12. Proc Natl Acad Sci U S A. 2009. PMID: 19706511 Free PMC article.

3

Evaluating the catalytic contribution from the oxyanion hole in ketosteroid isomerase.

Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. Schwans JP, et al. J Am Chem Soc. 2011 Dec 21;133(50):20052-5. doi: 10.1021/ja208050t. Epub 2011 Nov 22. J Am Chem Soc. 2011. PMID: 22053826 Free PMC article.

4

Use of anion-aromatic interactions to position the general base in the ketosteroid isomerase active site.

Schwans JP, Sunden F, Lassila JK, Gonzalez A, Tsai Y, Herschlag D. Schwans JP, et al. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11308-13. doi: 10.1073/pnas.1206710110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798413 Free PMC article.

5

Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase.

Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. Schwans JP, et al. Biochemistry. 2013 Nov 5;52(44):7840-55. doi: 10.1021/bi401083b. Epub 2013 Oct 23. Biochemistry. 2013. PMID: 24151972 Free PMC article.

6

Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site.

Schwans JP, Hanoian P, Lengerich BJ, Sunden F, Gonzalez A, Tsai Y, Hammes-Schiffer S, Herschlag D. Schwans JP, et al. Biochemistry. 2014 Apr 22;53(15):2541-55. doi: 10.1021/bi401671t. Epub 2014 Apr 9. Biochemistry. 2014. PMID: 24597914 Free PMC article.

7

Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site.

Natarajan A, Schwans JP, Herschlag D. Natarajan A, et al. Among authors: schwans jp. J Am Chem Soc. 2014 May 28;136(21):7643-54. doi: 10.1021/ja413174b. Epub 2014 May 14. J Am Chem Soc. 2014. PMID: 24787954 Free PMC article.

8

BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase".

Natarajan A, Yabukarski F, Lamba V, Schwans JP, Sunden F, Herschlag D. Natarajan A, et al. Among authors: schwans jp. Science. 2015 Aug 28;349(6251):936. doi: 10.1126/science.aab1584. Epub 2015 Aug 27. Science. 2015. PMID: 26315426

9

Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase.

Fafarman AT, Sigala PA, Schwans JP, Fenn TD, Herschlag D, Boxer SG. Fafarman AT, et al. Among authors: schwans jp. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):E299-308. doi: 10.1073/pnas.1111566109. Epub 2012 Jan 17. Proc Natl Acad Sci U S A. 2012. PMID: 22308339 Free PMC article.

10

Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site.

Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JM, Pybus B, Ringe D, Petsko GA, Boxer SG, Herschlag D. Sigala PA, et al. Among authors: schwans jp. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):E2552-61. doi: 10.1073/pnas.1302191110. Epub 2013 Jun 24. Proc Natl Acad Sci U S A. 2013. PMID: 23798390 Free PMC article.

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