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Page 1
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.
Hashimoto K, Saito B, Miyamoto N, Oguro Y, Tomita D, Shiokawa Z, Asano M, Kakei H, Taya N, Kawasaki M, Sumi H, Yabuki M, Iwai K, Yoshida S, Yoshimatsu M, Aoyama K, Kosugi Y, Kojima T, Morishita N, Dougan DR, Snell GP, Imamura S, Ishikawa T. Hashimoto K, et al. Among authors: kawasaki m. J Med Chem. 2013 Feb 14;56(3):1228-46. doi: 10.1021/jm301674z. Epub 2013 Jan 29. J Med Chem. 2013. PMID: 23298277
Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.
Mikami S, Nakamura S, Ashizawa T, Nomura I, Kawasaki M, Sasaki S, Oki H, Kokubo H, Hoffman ID, Zou H, Uchiyama N, Nakashima K, Kamiguchi N, Imada H, Suzuki N, Iwashita H, Taniguchi T. Mikami S, et al. Among authors: kawasaki m. J Med Chem. 2017 Sep 28;60(18):7677-7702. doi: 10.1021/acs.jmedchem.7b00807. Epub 2017 Sep 5. J Med Chem. 2017. PMID: 28796496
Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders.
Mikami S, Kawasaki M, Ikeda S, Negoro N, Nakamura S, Nomura I, Ashizawa T, Kokubo H, Hoffman ID, Zou H, Oki H, Uchiyama N, Hiura Y, Miyamoto M, Itou Y, Nakashima M, Iwashita H, Taniguchi T. Mikami S, et al. Among authors: kawasaki m. Chem Pharm Bull (Tokyo). 2017;65(11):1058-1077. doi: 10.1248/cpb.c17-00564. Chem Pharm Bull (Tokyo). 2017. PMID: 29093293 Free article.
Risk factors of late arrhythmia recurrences over 12 months after catheter ablation of atrial fibrillation: Insight into atrial cardiomyopathy.
Matsunaga-Lee Y, Inoue K, Tanaka N, Masuda M, Watanabe T, Minamiguchi H, Egami Y, Oka T, Miyoshi M, Okada M, Matsuda Y, Kawasaki M, Kawanami S, Ukita K, Kawamura A, Yasumoto K, Okamoto N, Yano M, Nishino M, Hikoso S, Sunaga A, Dohi T, Okada K, Nakatani D, Sotomi Y, Sakata Y; Osaka Cardiovascular Conference (OCVC)-Arrhythmia Investigators. Matsunaga-Lee Y, et al. Among authors: kawasaki m. Heart Rhythm. 2024 Dec 17:S1547-5271(24)03691-9. doi: 10.1016/j.hrthm.2024.12.018. Online ahead of print. Heart Rhythm. 2024. PMID: 39701441 No abstract available.
Gestational diabetes in early pregnancy is associated with postpartum glucose intolerance: A perspective from the diabetes and pregnancy outcome for mother and baby study in Japan.
Yokoyama M, Miyakoshi K, Iwama N, Yamashita H, Yasuhi I, Kawasaki M, Arata N, Sato S, Imura Y, Waguri M, Kawaguchi H, Masaoka N, Nakajima Y, Hiramatsu Y, Sugiyama T; DREAMBee Study Gestational Diabetes Mellitus Group. Yokoyama M, et al. Among authors: kawasaki m. J Diabetes Investig. 2024 Nov 28. doi: 10.1111/jdi.14368. Online ahead of print. J Diabetes Investig. 2024. PMID: 39610144 Free article.
Nitrogen gas-bubble disease in two giant salamanders.
Kadekaru S, Nakamura SI, Toriyama R, Kawasaki M, Ishisaka Y, Une Y. Kadekaru S, et al. Among authors: kawasaki m. Dis Aquat Organ. 2024 Nov 28;160:95-100. doi: 10.3354/dao03829. Dis Aquat Organ. 2024. PMID: 39607053
Na+-V-ATPase inhibitor curbs VRE growth and unveils Na+ pathway structure.
Suzuki K, Goto Y, Otomo A, Shimizu K, Abe S, Moriyama K, Yasuda S, Hashimoto Y, Kurushima J, Mikuriya S, Imai FL, Adachi N, Kawasaki M, Sato Y, Ogasawara S, Iwata S, Senda T, Ikeguchi M, Tomita H, Iino R, Moriya T, Murata T. Suzuki K, et al. Among authors: kawasaki m. Nat Struct Mol Biol. 2024 Nov 21. doi: 10.1038/s41594-024-01419-y. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 39572733
1,513 results