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Page 1
LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis.
Ribeiro GA, Cunha-Júnior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC. Ribeiro GA, et al. Among authors: da silva sa, da silva aj. J Antimicrob Chemother. 2013 Apr;68(4):789-99. doi: 10.1093/jac/dks498. Epub 2013 Jan 3. J Antimicrob Chemother. 2013. PMID: 23288404
LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells.
Maia RC, Vasconcelos FC, de Sá Bacelar T, Salustiano EJ, da Silva LF, Pereira DL, Moellman-Coelho A, Netto CD, da Silva AJ, Rumjanek VM, Costa PR. Maia RC, et al. Among authors: da silva aj, da silva lf. Invest New Drugs. 2011 Dec;29(6):1143-55. doi: 10.1007/s10637-010-9453-z. Epub 2010 May 25. Invest New Drugs. 2011. PMID: 20499132
Effectiveness of the local or oral delivery of the novel naphthopterocarpanquinone LQB-118 against cutaneous leishmaniasis.
da Cunha-Júnior EF, Pacienza-Lima W, Ribeiro GA, Netto CD, do Canto-Cavalheiro MM, da Silva AJ, Costa PR, Rossi-Bergmann B, Torres-Santos EC. da Cunha-Júnior EF, et al. Among authors: da silva aj. J Antimicrob Chemother. 2011 Jul;66(7):1555-9. doi: 10.1093/jac/dkr158. Epub 2011 Apr 29. J Antimicrob Chemother. 2011. PMID: 21531758
The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells.
de Souza Reis FR, de Faria FC, Castro CP, de Souza PS, da Cunha Vasconcelos F, Bello RD, da Silva AJ, Costa PR, Maia RC. de Souza Reis FR, et al. Among authors: da silva aj, da cunha vasconcelos f. Anticancer Agents Med Chem. 2013 Feb;13(2):341-51. doi: 10.2174/1871520611313020019. Anticancer Agents Med Chem. 2013. PMID: 22721384
Further evidence that naphthoquinone inhibits Toxoplasma gondii growth in vitro.
da Silva LL, Portes Jde A, de Araújo MH, Silva JL, Rennó MN, Netto CD, da Silva AJ, Costa PR, De Souza W, Seabra SH, DaMatta RA. da Silva LL, et al. Among authors: da silva aj, silva jl. Parasitol Int. 2015 Dec;64(6):622-31. doi: 10.1016/j.parint.2015.08.010. Epub 2015 Sep 1. Parasitol Int. 2015. PMID: 26335616
Low doses of 3-phenyl-lawsone or meglumine antimoniate delivery by tattooing route are successful in reducing parasite load in cutaneous lesions of Leishmania (Viannia) braziliensis-infected hamsters.
Meira RMV, Gomes SLDS, Schaeffer E, Da Silva T, Brito ACS, Siqueira LM, Inácio JD, Almeida-Amaral EE, Da-Cruz AM, Bezerra-Paiva M, Neves RH, Rodrigues LS, Dutra PML, Costa PRR, da Silva AJM, Da-Silva SAG. Meira RMV, et al. Front Cell Infect Microbiol. 2023 Jan 19;13:1025359. doi: 10.3389/fcimb.2023.1025359. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 36743305 Free PMC article.
324 results