Hyatt JL - Search Results

1

Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").

Hatfield MJ, Tsurkan LG, Hyatt JL, Edwards CC, Lemoff A, Jeffries C, Yan B, Potter PM. Hatfield MJ, et al. Among authors: hyatt jl. J Nat Prod. 2013 Jan 25;76(1):36-44. doi: 10.1021/np300628a. Epub 2013 Jan 3. J Nat Prod. 2013. PMID: 23286284 Free PMC article.

2

Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.

Hatfield MJ, Tsurkan L, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM. Hatfield MJ, et al. Among authors: hyatt jl. Br J Pharmacol. 2010 Aug;160(8):1916-28. doi: 10.1111/j.1476-5381.2010.00700.x. Br J Pharmacol. 2010. PMID: 20649590 Free PMC article.

3

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.

Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM. Hyatt JL, et al. Mol Cancer Ther. 2006 Sep;5(9):2281-8. doi: 10.1158/1535-7163.MCT-06-0160. Mol Cancer Ther. 2006. PMID: 16985062

4

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors.

Tsurkan LG, Hatfield MJ, Edwards CC, Hyatt JL, Potter PM. Tsurkan LG, et al. Among authors: hyatt jl. Chem Biol Interact. 2013 Mar 25;203(1):226-30. doi: 10.1016/j.cbi.2012.10.018. Epub 2012 Nov 2. Chem Biol Interact. 2013. PMID: 23123248 Free PMC article.

5

Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.

Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM. Hicks LD, et al. Among authors: hyatt jl. J Med Chem. 2009 Jun 25;52(12):3742-52. doi: 10.1021/jm9001296. J Med Chem. 2009. PMID: 19534556 Free PMC article.

6

An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.

Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM. Wierdl M, et al. Among authors: hyatt jl. Cancer Gene Ther. 2008 Mar;15(3):183-92. doi: 10.1038/sj.cgt.7701112. Epub 2008 Jan 11. Cancer Gene Ther. 2008. PMID: 18188187

7

Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.

Yoon KJ, Hyatt JL, Morton CL, Lee RE, Potter PM, Danks MK. Yoon KJ, et al. Among authors: hyatt jl. Mol Cancer Ther. 2004 Aug;3(8):903-9. Mol Cancer Ther. 2004. PMID: 15299073

8

Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.

Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM. Hyatt JL, et al. J Med Chem. 2005 Aug 25;48(17):5543-50. doi: 10.1021/jm0504196. J Med Chem. 2005. PMID: 16107154

9

Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.

Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. Hyatt JL, et al. Chem Biol Interact. 2005 Dec 15;157-158:247-52. doi: 10.1016/j.cbi.2005.10.033. Epub 2005 Oct 28. Chem Biol Interact. 2005. PMID: 16257398

10

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM. Hyatt JL, et al. J Med Chem. 2007 Apr 19;50(8):1876-85. doi: 10.1021/jm061471k. Epub 2007 Mar 23. J Med Chem. 2007. PMID: 17378546

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