Shukla S - Search Results

1

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.

Duveau DY, Hu X, Walsh MJ, Shukla S, Skoumbourdis AP, Boxer MB, Ambudkar SV, Shen M, Thomas CJ. Duveau DY, et al. Among authors: shukla s. Bioorg Med Chem Lett. 2013 Feb 1;23(3):682-6. doi: 10.1016/j.bmcl.2012.11.111. Epub 2012 Dec 10. Bioorg Med Chem Lett. 2013. PMID: 23273517 Free PMC article.

2

Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.

Shukla S, Chufan EE, Singh S, Skoumbourdis AP, Kapoor K, Boxer MB, Duveau DY, Thomas CJ, Talele TT, Ambudkar SV. Shukla S, et al. Leukemia. 2014 Apr;28(4):961-4. doi: 10.1038/leu.2014.21. Epub 2014 Jan 14. Leukemia. 2014. PMID: 24418991 Free PMC article. No abstract available.

3

Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2.

Shukla S, Robey RW, Bates SE, Ambudkar SV. Shukla S, et al. Drug Metab Dispos. 2009 Feb;37(2):359-65. doi: 10.1124/dmd.108.024612. Epub 2008 Oct 29. Drug Metab Dispos. 2009. PMID: 18971320 Free PMC article.

4

Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib.

Dohse M, Scharenberg C, Shukla S, Robey RW, Volkmann T, Deeken JF, Brendel C, Ambudkar SV, Neubauer A, Bates SE. Dohse M, et al. Among authors: shukla s. Drug Metab Dispos. 2010 Aug;38(8):1371-80. doi: 10.1124/dmd.109.031302. Epub 2010 Apr 27. Drug Metab Dispos. 2010. PMID: 20423956 Free PMC article.

5

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.

Shukla S, Skoumbourdis AP, Walsh MJ, Hartz AM, Fung KL, Wu CP, Gottesman MM, Bauer B, Thomas CJ, Ambudkar SV. Shukla S, et al. Mol Pharm. 2011 Aug 1;8(4):1292-302. doi: 10.1021/mp2001022. Epub 2011 Jun 16. Mol Pharm. 2011. PMID: 21630681 Free PMC article.

6

Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance.

Shukla S, Chen ZS, Ambudkar SV. Shukla S, et al. Drug Resist Updat. 2012 Feb-Apr;15(1-2):70-80. doi: 10.1016/j.drup.2012.01.005. Epub 2012 Feb 9. Drug Resist Updat. 2012. PMID: 22325423 Free PMC article. Review.

7

Pharmacophore modeling of nilotinib as an inhibitor of ATP-binding cassette drug transporters and BCR-ABL kinase using a three-dimensional quantitative structure-activity relationship approach.

Shukla S, Kouanda A, Silverton L, Talele TT, Ambudkar SV. Shukla S, et al. Mol Pharm. 2014 Jul 7;11(7):2313-22. doi: 10.1021/mp400762h. Epub 2014 Jun 5. Mol Pharm. 2014. PMID: 24865254 Free PMC article.

8

Development of inhibitors of ATP-binding cassette drug transporters: present status and challenges.

Shukla S, Wu CP, Ambudkar SV. Shukla S, et al. Expert Opin Drug Metab Toxicol. 2008 Feb;4(2):205-23. doi: 10.1517/17425255.4.2.205. Expert Opin Drug Metab Toxicol. 2008. PMID: 18248313 Review.

9

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.

Sauna ZE, Shukla S, Ambudkar SV. Sauna ZE, et al. Among authors: shukla s. Mol Biosyst. 2005 Jul;1(2):127-34. doi: 10.1039/b504392a. Epub 2005 May 26. Mol Biosyst. 2005. PMID: 16880974 Review.

10

Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2.

Bakhsheshian J, Wei BR, Chang KE, Shukla S, Ambudkar SV, Simpson RM, Gottesman MM, Hall MD. Bakhsheshian J, et al. Among authors: shukla s. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20801-6. doi: 10.1073/pnas.1312159110. Epub 2013 Dec 2. Proc Natl Acad Sci U S A. 2013. PMID: 24297888 Free PMC article.

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