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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
Palles C, Cazier JB, Howarth KM, Domingo E, Jones AM, Broderick P, Kemp Z, Spain SL, Guarino E, Salguero I, Sherborne A, Chubb D, Carvajal-Carmona LG, Ma Y, Kaur K, Dobbins S, Barclay E, Gorman M, Martin L, Kovac MB, Humphray S; CORGI Consortium; WGS500 Consortium; Lucassen A, Holmes CC, Bentley D, Donnelly P, Taylor J, Petridis C, Roylance R, Sawyer EJ, Kerr DJ, Clark S, Grimes J, Kearsey SE, Thomas HJ, McVean G, Houlston RS, Tomlinson I. Palles C, et al. Among authors: kearsey se. Nat Genet. 2013 Feb;45(2):136-44. doi: 10.1038/ng.2503. Epub 2012 Dec 23. Nat Genet. 2013. PMID: 23263490 Free PMC article.
Cellular regulation of ribonucleotide reductase in eukaryotes.
Guarino E, Salguero I, Kearsey SE. Guarino E, et al. Among authors: kearsey se. Semin Cell Dev Biol. 2014 Jun;30:97-103. doi: 10.1016/j.semcdb.2014.03.030. Epub 2014 Apr 2. Semin Cell Dev Biol. 2014. PMID: 24704278 Review.
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
Soriano I, Vazquez E, De Leon N, Bertrand S, Heitzer E, Toumazou S, Bo Z, Palles C, Pai CC, Humphrey TC, Tomlinson I, Cotterill S, Kearsey SE. Soriano I, et al. Among authors: kearsey se. PLoS Genet. 2021 Jul 6;17(7):e1009526. doi: 10.1371/journal.pgen.1009526. eCollection 2021 Jul. PLoS Genet. 2021. PMID: 34228709 Free PMC article.
73 results