Chambers JW - Search Results

1

Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats.

Chambers JW, Pachori A, Howard S, Iqbal S, LoGrasso PV. Chambers JW, et al. J Biol Chem. 2013 Feb 8;288(6):4000-11. doi: 10.1074/jbc.M112.406777. Epub 2012 Dec 20. J Biol Chem. 2013. PMID: 23258542 Free PMC article.

2

Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation.

Chambers JW, LoGrasso PV. Chambers JW, et al. J Biol Chem. 2011 May 6;286(18):16052-62. doi: 10.1074/jbc.M111.223602. Epub 2011 Mar 16. J Biol Chem. 2011. PMID: 21454558 Free PMC article.

3

Selective inhibition of mitochondrial JNK signaling achieved using peptide mimicry of the Sab kinase interacting motif-1 (KIM1).

Chambers JW, Cherry L, Laughlin JD, Figuera-Losada M, Lograsso PV. Chambers JW, et al. ACS Chem Biol. 2011 Aug 19;6(8):808-18. doi: 10.1021/cb200062a. Epub 2011 May 24. ACS Chem Biol. 2011. PMID: 21563797 Free PMC article.

4

Blocking c-Jun N-terminal kinase (JNK) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo.

Chambers JW, Howard S, LoGrasso PV. Chambers JW, et al. J Biol Chem. 2013 Jan 11;288(2):1079-87. doi: 10.1074/jbc.M112.421354. Epub 2012 Nov 26. J Biol Chem. 2013. PMID: 23184940 Free PMC article.

5

A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.

Feng Y, Chambers JW, Iqbal S, Koenig M, Park H, Cherry L, Hernandez P, Figuera-Losada M, LoGrasso PV. Feng Y, et al. Among authors: chambers jw. ACS Chem Biol. 2013 Aug 16;8(8):1747-54. doi: 10.1021/cb3006165. Epub 2013 Jun 10. ACS Chem Biol. 2013. PMID: 23751758 Free PMC article.

6

Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors.

Kamenecka T, Jiang R, Song X, Duckett D, Chen W, Ling YY, Habel J, Laughlin JD, Chambers J, Figuera-Losada M, Cameron MD, Lin L, Ruiz CH, LoGrasso PV. Kamenecka T, et al. J Med Chem. 2010 Jan 14;53(1):419-31. doi: 10.1021/jm901351f. J Med Chem. 2010. PMID: 19947601 Free PMC article.

7

Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease.

Chambers JW, Pachori A, Howard S, Ganno M, Hansen D Jr, Kamenecka T, Song X, Duckett D, Chen W, Ling YY, Cherry L, Cameron MD, Lin L, Ruiz CH, Lograsso P. Chambers JW, et al. ACS Chem Neurosci. 2011 Apr 20;2(4):198-206. doi: 10.1021/cn100109k. ACS Chem Neurosci. 2011. PMID: 21666839 Free PMC article.

8

Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53-dependent mechanism: implications for long-term culture expansion.

Boregowda SV, Krishnappa V, Chambers JW, Lograsso PV, Lai WT, Ortiz LA, Phinney DG. Boregowda SV, et al. Among authors: chambers jw. Stem Cells. 2012 May;30(5):975-87. doi: 10.1002/stem.1069. Stem Cells. 2012. PMID: 22367737 Free PMC article.

9

Sub-chronic administration of LY294002 sensitizes cervical cancer cells to chemotherapy by enhancing mitochondrial JNK signaling.

Chambers TP, Portalatin GM, Paudel I, Robbins CJ, Chambers JW. Chambers TP, et al. Among authors: chambers jw. Biochem Biophys Res Commun. 2015 Aug 7;463(4):538-44. doi: 10.1016/j.bbrc.2015.05.075. Epub 2015 May 30. Biochem Biophys Res Commun. 2015. PMID: 26032505

10

Sab mediates mitochondrial dysfunction involved in imatinib mesylate-induced cardiotoxicity.

Chambers TP, Santiesteban L, Gomez D, Chambers JW. Chambers TP, et al. Among authors: chambers jw. Toxicology. 2017 May 1;382:24-35. doi: 10.1016/j.tox.2017.03.006. Epub 2017 Mar 16. Toxicology. 2017. PMID: 28315715

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