Greenlee W - Search Results

1

The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.

Li H, Qin J, Dhondi P, Zhou W, Vicarel M, Bara T, Cole D, Josien H, Pissarnitski D, Zhu Z, Palani A, Aslanian R, Clader J, Czarniecki M, Greenlee W, Cohen-Williams M, Hyde L, Song L, Zhang L, Chu I, Huang X. Li H, et al. Among authors: greenlee w. Bioorg Med Chem Lett. 2013 Jan 15;23(2):466-71. doi: 10.1016/j.bmcl.2012.11.055. Epub 2012 Nov 29. Bioorg Med Chem Lett. 2013. PMID: 23253441

2

Inhibitors of human renin with C-termini derived from amides and esters of alpha-mercaptoalkanoic acids.

Ashton WT, Cantone CL, Tolman RL, Greenlee WJ, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: greenlee wj. J Med Chem. 1992 Jul 24;35(15):2772-81. doi: 10.1021/jm00093a009. J Med Chem. 1992. PMID: 1495010

3

Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors.

de Laszlo SE, Bush BL, Doyle JJ, Greenlee WJ, Hangauer DG, Halgren TA, Lynch RJ, Schorn TW, Siegl PK. de Laszlo SE, et al. Among authors: greenlee wj. J Med Chem. 1992 Mar 6;35(5):833-46. doi: 10.1021/jm00083a006. J Med Chem. 1992. PMID: 1548675

4

Renin inhibitors containing C-termini derived from mercaptoheterocycles.

Ashton WT, Cantone CL, Meurer LC, Tolman RL, Greenlee WJ, Patchett AA, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: greenlee wj. J Med Chem. 1992 May 29;35(11):2103-12. doi: 10.1021/jm00089a023. J Med Chem. 1992. PMID: 1597860

5

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.

Weber AE, Halgren TA, Doyle JJ, Lynch RJ, Siegl PK, Parsons WH, Greenlee WJ, Patchett AA. Weber AE, et al. Among authors: greenlee wj. J Med Chem. 1991 Sep;34(9):2692-701. doi: 10.1021/jm00113a005. J Med Chem. 1991. PMID: 1895289

6

Synthesis of an analogue of tabtoxinine as a potential inhibitor of D-alanine:D-alanine ligase (ADP forming).

Greenlee WJ, Springer JP, Patchett AA. Greenlee WJ, et al. J Med Chem. 1989 Jan;32(1):165-70. doi: 10.1021/jm00121a030. J Med Chem. 1989. PMID: 2562853

7

Triazolinone biphenylsulfonamide derivatives as orally active angiotensin II antagonists with potent AT1 receptor affinity and enhanced AT2 affinity.

Ashton WT, Chang LL, Flanagan KL, Hutchins SM, Naylor EM, Chakravarty PK, Patchett AA, Greenlee WJ, Chen TB, Faust KA, et al. Ashton WT, et al. Among authors: greenlee wj. J Med Chem. 1994 Aug 19;37(17):2808-24. doi: 10.1021/jm00043a020. J Med Chem. 1994. PMID: 8064808

8

A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor.

de Laszlo SE, Quagliato CS, Greenlee WJ, Patchett AA, Chang RS, Lotti VJ, Chen TB, Scheck SA, Faust KA, Kivlighn SS, et al. de Laszlo SE, et al. Among authors: greenlee wj. J Med Chem. 1993 Oct 15;36(21):3207-10. doi: 10.1021/jm00073a024. J Med Chem. 1993. PMID: 8230109 No abstract available.

9

Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates.

Ashton WT, Hutchins SM, Greenlee WJ, Doss GA, Chang RS, Lotti VJ, Faust KA, Chen TB, Zingaro GJ, Kivlighn SD, et al. Ashton WT, et al. Among authors: greenlee wj. J Med Chem. 1993 Nov 12;36(23):3595-605. doi: 10.1021/jm00075a014. J Med Chem. 1993. PMID: 8246227

10

Non-peptide angiotensin II receptor antagonists. 1. Design, synthesis, and biological activity of N-substituted indoles and dihydroindoles.

Dhanoa DS, Bagley SW, Chang RS, Lotti VJ, Chen TB, Kivlighn SD, Zingaro GJ, Siegl PK, Patchett AA, Greenlee WJ. Dhanoa DS, et al. Among authors: greenlee wj. J Med Chem. 1993 Dec 24;36(26):4230-8. doi: 10.1021/jm00078a013. J Med Chem. 1993. PMID: 8277505

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