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The discovery, engineering and characterisation of a highly potent anti-human IL-13 fab fragment designed for administration by inhalation.
Lightwood D, O'Dowd V, Carrington B, Veverka V, Carr MD, Tservistas M, Henry AJ, Smith B, Tyson K, Lamour S, Bracher M, Sarkar K, Turner A, Lawson AD, Bourne T, Gozzard N, Palframan R. Lightwood D, et al. Among authors: palframan r. J Mol Biol. 2013 Feb 8;425(3):577-93. doi: 10.1016/j.jmb.2012.11.036. Epub 2012 Dec 3. J Mol Biol. 2013. PMID: 23219467
Corrigendum to "The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation" [J. Mol. Biol. 425 (2013), 577-593].
Lightwood D, O'Dowd V, Carrington B, Veverka V, Carr MD, Tservistas M, Henry AJ, Smith B, Tyson K, Lamour S, Bracher M, Sarkar K, Turner A, Lawson AD, Bourne T, Gozzard N, Palframan R. Lightwood D, et al. Among authors: palframan r. J Mol Biol. 2013 Jun 12;425(11):2082. doi: 10.1016/j.jmb.2013.03.038. Epub 2013 Apr 5. J Mol Biol. 2013. PMID: 29890570 No abstract available.
Efficacy of an Inhaled IL-13 Antibody Fragment in a Model of Chronic Asthma.
Lightwood D, Tservistas M, Zehentleitner M, Sarkar K, Turner A, Bracher M, Smith B, Lamour S, Bourne T, Shaw S, Gozzard N, Palframan RT. Lightwood D, et al. Among authors: palframan rt. Am J Respir Crit Care Med. 2018 Sep 1;198(5):610-619. doi: 10.1164/rccm.201712-2382OC. Am J Respir Crit Care Med. 2018. PMID: 29883204
Alternative antibody Fab' fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering.
Humphreys DP, Heywood SP, Henry A, Ait-Lhadj L, Antoniw P, Palframan R, Greenslade KJ, Carrington B, Reeks DG, Bowering LC, West S, Brand HA. Humphreys DP, et al. Among authors: palframan r. Protein Eng Des Sel. 2007 May;20(5):227-34. doi: 10.1093/protein/gzm015. Epub 2007 Apr 23. Protein Eng Des Sel. 2007. PMID: 17452434
In vitro and in vivo characterisation of anti-murine IL-13 antibodies recognising distinct functional epitopes.
Berry LM, Adams R, Airey M, Bracher MG, Bourne T, Carrington B, Cross AS, Davies GC, Finney HM, Foulkes R, Gozzard N, Griffin RA, Hailu H, Lamour SD, Lawson AD, Lightwood DJ, McKnight AJ, O'Dowd VL, Oxbrow AK, Popplewell AG, Shaw S, Stephens PE, Sweeney B, Tomlinson KL, Uhe C, Palframan RT. Berry LM, et al. Among authors: palframan rt. Int Immunopharmacol. 2009 Feb;9(2):201-6. doi: 10.1016/j.intimp.2008.11.001. Epub 2008 Nov 27. Int Immunopharmacol. 2009. PMID: 19041426
Nebulized anti-IL-13 monoclonal antibody Fab' fragment reduces allergen-induced asthma.
Hacha J, Tomlinson K, Maertens L, Paulissen G, Rocks N, Foidart JM, Noel A, Palframan R, Gueders M, Cataldo DD. Hacha J, et al. Among authors: palframan r. Am J Respir Cell Mol Biol. 2012 Nov;47(5):709-17. doi: 10.1165/rcmb.2012-0031OC. Epub 2012 Aug 16. Am J Respir Cell Mol Biol. 2012. PMID: 22904197 Free article.
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