Haslett C - Search Results

1

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway.

Lucas CD, Allen KC, Dorward DA, Hoodless LJ, Melrose LA, Marwick JA, Tucker CS, Haslett C, Duffin R, Rossi AG. Lucas CD, et al. Among authors: haslett c. FASEB J. 2013 Mar;27(3):1084-94. doi: 10.1096/fj.12-218990. Epub 2012 Nov 29. FASEB J. 2013. PMID: 23195034 Free PMC article. Clinical Trial.

2

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1.

Duffin R, Leitch AE, Sheldrake TA, Hallett JM, Meyer C, Fox S, Alessandri AL, Martin MC, Brady HJ, Teixeira MM, Dransfield I, Haslett C, Rossi AG. Duffin R, et al. Among authors: haslett c. FEBS Lett. 2009 Aug 6;583(15):2540-6. doi: 10.1016/j.febslet.2009.07.017. Epub 2009 Jul 18. FEBS Lett. 2009. PMID: 19616548 Free article.

3

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis.

Leitch AE, Riley NA, Sheldrake TA, Festa M, Fox S, Duffin R, Haslett C, Rossi AG. Leitch AE, et al. Among authors: haslett c. Eur J Immunol. 2010 Apr;40(4):1127-38. doi: 10.1002/eji.200939664. Eur J Immunol. 2010. PMID: 20127676 Free article.

4

Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments.

Marwick JA, Dorward DA, Lucas CD, Jones KO, Sheldrake TA, Fox S, Ward C, Murray J, Brittan M, Hirani N, Duffin R, Dransfield I, Haslett C, Rossi AG. Marwick JA, et al. Among authors: haslett c. J Leukoc Biol. 2013 Dec;94(6):1285-92. doi: 10.1189/jlb.0912462. Epub 2013 Aug 20. J Leukoc Biol. 2013. PMID: 23964116 Free PMC article. Clinical Trial.

5

Genetic and pharmacological inhibition of CDK9 drives neutrophil apoptosis to resolve inflammation in zebrafish in vivo.

Hoodless LJ, Lucas CD, Duffin R, Denvir MA, Haslett C, Tucker CS, Rossi AG. Hoodless LJ, et al. Among authors: haslett c. Sci Rep. 2016 Nov 11;5:36980. doi: 10.1038/srep36980. Sci Rep. 2016. PMID: 27833165 Free PMC article.

6

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation.

Leitch AE, Lucas CD, Marwick JA, Duffin R, Haslett C, Rossi AG. Leitch AE, et al. Among authors: haslett c. Cell Death Differ. 2012 Dec;19(12):1950-61. doi: 10.1038/cdd.2012.80. Epub 2012 Jun 29. Cell Death Differ. 2012. PMID: 22743999 Free PMC article.

7

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung.

Lucas CD, Dorward DA, Tait MA, Fox S, Marwick JA, Allen KC, Robb CT, Hirani N, Haslett C, Duffin R, Rossi AG. Lucas CD, et al. Among authors: haslett c. Mucosal Immunol. 2014 Jul;7(4):857-68. doi: 10.1038/mi.2013.102. Epub 2013 Nov 27. Mucosal Immunol. 2014. PMID: 24280938 Free PMC article.

8

Mcl-1 protects eosinophils from apoptosis and exacerbates allergic airway inflammation.

Felton JM, Dorward DA, Cartwright JA, Potey PM, Robb CT, Gui J, Craig RW, Schwarze J, Haslett C, Duffin R, Dransfield I, Lucas CD, Rossi AG. Felton JM, et al. Among authors: haslett c. Thorax. 2020 Jul;75(7):600-605. doi: 10.1136/thoraxjnl-2019-213204. Epub 2020 Apr 17. Thorax. 2020. PMID: 32303624 Free PMC article.

9

Targeting granulocyte apoptosis: mechanisms, models, and therapies.

Duffin R, Leitch AE, Fox S, Haslett C, Rossi AG. Duffin R, et al. Among authors: haslett c. Immunol Rev. 2010 Jul;236:28-40. doi: 10.1111/j.1600-065X.2010.00922.x. Immunol Rev. 2010. PMID: 20636806 Review.

10

Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps.

Gray RD, Lucas CD, MacKellar A, Li F, Hiersemenzel K, Haslett C, Davidson DJ, Rossi AG. Gray RD, et al. Among authors: haslett c. J Inflamm (Lond). 2013 Mar 21;10(1):12. doi: 10.1186/1476-9255-10-12. J Inflamm (Lond). 2013. PMID: 23514610 Free PMC article.

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