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CDK inhibitor p57 (Kip2) is negatively regulated by COP9 signalosome subunit 6.
Chen B, Zhao R, Su CH, Linan M, Tseng C, Phan L, Fang L, Yang HY, Yang H, Wang W, Xu X, Jiang N, Cai S, Jin F, Yeung SC, Lee MH. Chen B, et al. Among authors: zhao r. Cell Cycle. 2012 Dec 15;11(24):4633-41. doi: 10.4161/cc.22887. Epub 2012 Nov 27. Cell Cycle. 2012. PMID: 23187808 Free PMC article.
Autophagy induced by farnesyltransferase inhibitors in cancer cells.
Pan J, Chen B, Su CH, Zhao R, Xu ZX, Sun L, Lee MH, Yeung SC. Pan J, et al. Among authors: zhao r. Cancer Biol Ther. 2008 Oct;7(10):1679-84. doi: 10.4161/cbt.7.10.6661. Epub 2008 Oct 21. Cancer Biol Ther. 2008. PMID: 18769123 Free article.
Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.
Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH. Chen J, et al. Among authors: zhao r. Am J Pathol. 2009 Jul;175(1):400-11. doi: 10.2353/ajpath.2009.080972. Epub 2009 Jun 15. Am J Pathol. 2009. PMID: 19528349 Free PMC article.
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Zhao R, et al. J Clin Invest. 2011 Mar;121(3):851-65. doi: 10.1172/JCI44111. Epub 2011 Feb 7. J Clin Invest. 2011. PMID: 21317535 Free PMC article.
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