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Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents.
Rui M, Rossi D, Marra A, Paolillo M, Schinelli S, Curti D, Tesei A, Cortesi M, Zamagni A, Laurini E, Pricl S, Schepmann D, Wűnsch B, Urban E, Pace V, Collina S. Rui M, et al. Among authors: curti d. Eur J Med Chem. 2016 Nov 29;124:649-665. doi: 10.1016/j.ejmech.2016.08.067. Epub 2016 Aug 31. Eur J Med Chem. 2016. PMID: 27614411
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.
Rui M, Rossino G, Coniglio S, Monteleone S, Scuteri A, Malacrida A, Rossi D, Catenacci L, Sorrenti M, Paolillo M, Curti D, Venturini L, Schepmann D, Wünsch B, Liedl KR, Cavaletti G, Pace V, Urban E, Collina S. Rui M, et al. Among authors: curti d. Eur J Med Chem. 2018 Oct 5;158:353-370. doi: 10.1016/j.ejmech.2018.09.010. Epub 2018 Sep 8. Eur J Med Chem. 2018. PMID: 30223122
Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: g-scale synthesis, physicochemical characterization and in vitro metabolic stability.
Rossi D, Marra A, Picconi P, Serra M, Catenacci L, Sorrenti M, Laurini E, Fermeglia M, Pricl S, Brambilla S, Almirante N, Peviani M, Curti D, Collina S. Rossi D, et al. Among authors: curti d. Bioorg Med Chem. 2013 May 1;21(9):2577-86. doi: 10.1016/j.bmc.2013.02.029. Epub 2013 Feb 26. Bioorg Med Chem. 2013. PMID: 23498917
Identification of a potent and selective σ₁ receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells.
Rossi D, Pedrali A, Urbano M, Gaggeri R, Serra M, Fernández L, Fernández M, Caballero J, Ronsisvalle S, Prezzavento O, Schepmann D, Wuensch B, Peviani M, Curti D, Azzolina O, Collina S. Rossi D, et al. Among authors: curti d. Bioorg Med Chem. 2011 Nov 1;19(21):6210-24. doi: 10.1016/j.bmc.2011.09.016. Epub 2011 Sep 14. Bioorg Med Chem. 2011. PMID: 21967807
Toward the identification of neuroprotective agents: g-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist.
Marra A, Rossi D, Pignataro L, Bigogno C, Canta A, Oggioni N, Malacrida A, Corbo M, Cavaletti G, Peviani M, Curti D, Dondio G, Collina S. Marra A, et al. Among authors: curti d. Future Med Chem. 2016;8(3):287-95. doi: 10.4155/fmc.15.191. Epub 2016 Feb 22. Future Med Chem. 2016. PMID: 26898712
Are sigma receptor modulators a weapon against multiple sclerosis disease?
Collina S, Rui M, Stotani S, Bignardi E, Rossi D, Curti D, Giordanetto F, Malacrida A, Scuteri A, Cavaletti G. Collina S, et al. Among authors: curti d. Future Med Chem. 2017 Nov;9(17):2029-2051. doi: 10.4155/fmc-2017-0122. Epub 2017 Oct 27. Future Med Chem. 2017. PMID: 29076758
91 results