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Comparison of mitochondrial mutation spectra in ageing human colonic epithelium and disease: absence of evidence for purifying selection in somatic mitochondrial DNA point mutations.
Greaves LC, Elson JL, Nooteboom M, Grady JP, Taylor GA, Taylor RW, Mathers JC, Kirkwood TB, Turnbull DM. Greaves LC, et al. Among authors: kirkwood tb. PLoS Genet. 2012;8(11):e1003082. doi: 10.1371/journal.pgen.1003082. Epub 2012 Nov 15. PLoS Genet. 2012. PMID: 23166522 Free PMC article.
Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing.
Greaves LC, Nooteboom M, Elson JL, Tuppen HA, Taylor GA, Commane DM, Arasaradnam RP, Khrapko K, Taylor RW, Kirkwood TB, Mathers JC, Turnbull DM. Greaves LC, et al. Among authors: kirkwood tb. PLoS Genet. 2014 Sep 18;10(9):e1004620. doi: 10.1371/journal.pgen.1004620. eCollection 2014 Sep. PLoS Genet. 2014. PMID: 25232829 Free PMC article.
Mitochondrial DNA mutations in human colonic crypt stem cells.
Taylor RW, Barron MJ, Borthwick GM, Gospel A, Chinnery PF, Samuels DC, Taylor GA, Plusa SM, Needham SJ, Greaves LC, Kirkwood TB, Turnbull DM. Taylor RW, et al. Among authors: kirkwood tb. J Clin Invest. 2003 Nov;112(9):1351-60. doi: 10.1172/JCI19435. J Clin Invest. 2003. PMID: 14597761 Free PMC article.
265 results