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Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus.
Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, Koepsell H, Cunard R, Sharma K, Thomson SC, Rieg T. Vallon V, et al. Among authors: koepsell h. Am J Physiol Renal Physiol. 2013 Jan 15;304(2):F156-67. doi: 10.1152/ajprenal.00409.2012. Epub 2012 Nov 14. Am J Physiol Renal Physiol. 2013. PMID: 23152292 Free PMC article.
SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.
Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, Koepsell H, Thomson SC, Rieg T. Vallon V, et al. Among authors: koepsell h. Am J Physiol Renal Physiol. 2014 Jan;306(2):F194-204. doi: 10.1152/ajprenal.00520.2013. Epub 2013 Nov 13. Am J Physiol Renal Physiol. 2014. PMID: 24226524 Free PMC article.
Gene deletion of the Na+-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion.
Nespoux J, Patel R, Hudkins KL, Huang W, Freeman B, Kim YC, Koepsell H, Alpers CE, Vallon V. Nespoux J, et al. Among authors: koepsell h. Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1201-F1210. doi: 10.1152/ajprenal.00111.2019. Epub 2019 Apr 17. Am J Physiol Renal Physiol. 2019. PMID: 30995111 Free PMC article.
Knockout of Na+-glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration.
Song P, Huang W, Onishi A, Patel R, Kim YC, van Ginkel C, Fu Y, Freeman B, Koepsell H, Thomson S, Liu R, Vallon V. Song P, et al. Among authors: koepsell h. Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F207-F217. doi: 10.1152/ajprenal.00120.2019. Epub 2019 May 15. Am J Physiol Renal Physiol. 2019. PMID: 31091127 Free PMC article.
SGLT2 mediates glucose reabsorption in the early proximal tubule.
Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T. Vallon V, et al. Among authors: koepsell h. J Am Soc Nephrol. 2011 Jan;22(1):104-12. doi: 10.1681/ASN.2010030246. Epub 2010 Jul 8. J Am Soc Nephrol. 2011. PMID: 20616166 Free PMC article.
Expression of Na+-D-glucose cotransporter SGLT2 in rodents is kidney-specific and exhibits sex and species differences.
Sabolic I, Vrhovac I, Eror DB, Gerasimova M, Rose M, Breljak D, Ljubojevic M, Brzica H, Sebastiani A, Thal SC, Sauvant C, Kipp H, Vallon V, Koepsell H. Sabolic I, et al. Among authors: koepsell h. Am J Physiol Cell Physiol. 2012 Apr 15;302(8):C1174-88. doi: 10.1152/ajpcell.00450.2011. Epub 2012 Jan 18. Am J Physiol Cell Physiol. 2012. PMID: 22262063 Free PMC article.
Unmasking a sustained negative effect of SGLT2 inhibition on body fluid volume in the rat.
Masuda T, Watanabe Y, Fukuda K, Watanabe M, Onishi A, Ohara K, Imai T, Koepsell H, Muto S, Vallon V, Nagata D. Masuda T, et al. Among authors: koepsell h. Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F653-F664. doi: 10.1152/ajprenal.00143.2018. Epub 2018 May 23. Am J Physiol Renal Physiol. 2018. PMID: 29790389 Free PMC article.
246 results