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Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.
Basarab GS, Ghorpade S, Gibhard L, Mueller R, Njoroge M, Peton N, Govender P, Massoudi LM, Robertson GT, Lenaerts AJ, Boshoff HI, Joerss D, Parish T, Durand-Reville TF, Perros M, Singh V, Chibale K. Basarab GS, et al. Among authors: boshoff hi. Antimicrob Agents Chemother. 2022 Apr 19;66(4):e0219221. doi: 10.1128/aac.02192-21. Epub 2022 Mar 10. Antimicrob Agents Chemother. 2022. PMID: 35266826 Free PMC article.
Bioactive pyridine-N-oxide disulfides from Allium stipitatum.
O'Donnell G, Poeschl R, Zimhony O, Gunaratnam M, Moreira JB, Neidle S, Evangelopoulos D, Bhakta S, Malkinson JP, Boshoff HI, Lenaerts A, Gibbons S. O'Donnell G, et al. Among authors: boshoff hi. J Nat Prod. 2009 Mar 27;72(3):360-5. doi: 10.1021/np800572r. J Nat Prod. 2009. PMID: 19093848 Free PMC article.
Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism.
Kavanagh ME, McLean KJ, Gilbert SH, Amadi C, Snee M, Tunnicliffe RB, Arora K, Boshoff HI, Fanourakis A, Rebello-Lopez MJ, Ortega-Muro F, Levy CW, Munro AW, Leys D, Abell C, Coyne AG. Kavanagh ME, et al. Among authors: boshoff hi. bioRxiv [Preprint]. 2024 Dec 3:2024.10.28.620643. doi: 10.1101/2024.10.28.620643. bioRxiv. 2024. PMID: 39803573 Free PMC article. Preprint.
Environmental sphagnum-associated fungi target thiol homeostasis to compete with Mycobacterium tuberculosis.
Malhotra N, Oh S, Finin P, Medrano J, Andrews J, Goodwin M, Markowitz TE, Lack J, Boshoff HIM, Barry CE. Malhotra N, et al. Among authors: boshoff him. bioRxiv [Preprint]. 2024 Sep 23:2024.09.23.614403. doi: 10.1101/2024.09.23.614403. bioRxiv. 2024. Update in: PLoS Biol. 2024 Dec 3;22(12):e3002852. doi: 10.1371/journal.pbio.3002852 PMID: 39372785 Free PMC article. Updated. Preprint.
Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs.
Bague D, Wang R, Hodge D, Mikati MO, Roma JS, Boshoff HI, Dailey AL, Girma M, Couch RD, Odom John AR, Dowd CS. Bague D, et al. Among authors: boshoff hi. RSC Med Chem. 2024 May 22;15(7):2422-2439. doi: 10.1039/d3md00642e. eCollection 2024 Jul 17. RSC Med Chem. 2024. PMID: 39026652 Free PMC article.
Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities.
Boshoff HIM, Young K, Ahn YM, Yadav VD, Crowley BM, Yang L, Su J, Oh S, Arora K, Andrews J, Manikkam M, Sutphin M, Smith AJ, Weiner DM, Piazza MK, Fleegle JD, Gomez F, Dayao EK, Prideaux B, Zimmerman M, Kaya F, Sarathy J, Tan VY, Via LE, Tschirret-Guth R, Lenaerts AJ, Robertson GT, Dartois V, Olsen DB, Barry CE 3rd. Boshoff HIM, et al. ACS Infect Dis. 2024 May 10;10(5):1679-1695. doi: 10.1021/acsinfecdis.4c00025. Epub 2024 Apr 6. ACS Infect Dis. 2024. PMID: 38581700
169 results