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Page 1
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK. Aslibekyan S, et al. Among authors: an p. Nutr Metab Cardiovasc Dis. 2013 Oct;23(10):987-94. doi: 10.1016/j.numecd.2012.07.010. Epub 2012 Nov 11. Nutr Metab Cardiovasc Dis. 2013. PMID: 23149075 Free PMC article.
BACKGROUND AND AIMS: Adiponectin is an adipose-secreted protein that has been linked to changes in insulin sensitivity, high-density lipoprotein cholesterol levels, and inflammatory patterns. ...We observed a statistically significant (P = 5 10-8) association betwee …
BACKGROUND AND AIMS: Adiponectin is an adipose-secreted protein that has been linked to changes in insulin sensitivity, high-density …
The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate.
Shen J, Arnett DK, Parnell LD, Lai CQ, Straka RJ, Hopkins PN, An P, Feitosa MF, Ordovás JM. Shen J, et al. Among authors: an p. J Cardiovasc Pharmacol. 2012 Mar;59(3):254-9. doi: 10.1097/FJC.0b013e31823de86b. J Cardiovasc Pharmacol. 2012. PMID: 22075751 Free PMC article. Clinical Trial.
INTRODUCTION: CYP7A1 encodes cholesterol 7alpha-hydroxylase, an enzyme crucial to cholesterol homeostasis. Its transcriptional activity is downregulated by fenofibrate. ...Individuals homozygous for the common T allele of m204T>G single nuclear polymorphism displayed bo …
INTRODUCTION: CYP7A1 encodes cholesterol 7alpha-hydroxylase, an enzyme crucial to cholesterol homeostasis. Its transcriptional activi …
The effect of a novel intergenic polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB polymorphism in the cholesterol ester transfer protein gene.
Junyent M, Lee YC, Smith CE, Arnett DK, Tsai MY, Kabagambe EK, Straka RJ, Province M, An P, Lai CQ, Parnell LD, Shen J, Borecki I, Ordovas JM. Junyent M, et al. Among authors: an p. Nutr Metab Cardiovasc Dis. 2010 Jan;20(1):34-40. doi: 10.1016/j.numecd.2009.02.010. Epub 2009 Apr 11. Nutr Metab Cardiovasc Dis. 2010. PMID: 19364639 Free PMC article.
ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study.
Junyent M, Parnell LD, Lai CQ, Arnett DK, Tsai MY, Kabagambe EK, Straka RJ, Province M, An P, Smith CE, Lee YC, Borecki I, Ordovás JM. Junyent M, et al. Among authors: an p. Nutr Metab Cardiovasc Dis. 2010 Dec;20(10):698-705. doi: 10.1016/j.numecd.2009.06.011. Epub 2009 Oct 9. Nutr Metab Cardiovasc Dis. 2010. PMID: 19819120 Free PMC article.
Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women.
Junyent M, Arnett DK, Tsai MY, Kabagambe EK, Straka RJ, Province M, An P, Lai CQ, Parnell LD, Shen J, Lee YC, Borecki I, Ordovás JM. Junyent M, et al. Among authors: an p. J Nutr. 2009 May;139(5):842-8. doi: 10.3945/jn.108.101196. Epub 2009 Mar 25. J Nutr. 2009. PMID: 19321583 Free PMC article.
Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study.
Junyent M, Parnell LD, Lai CQ, Lee YC, Smith CE, Arnett DK, Tsai MY, Kabagambe EK, Straka RJ, Province M, An P, Borecki I, Ordovás JM. Junyent M, et al. Among authors: an p. Am J Clin Nutr. 2009 Sep;90(3):686-94. doi: 10.3945/ajcn.2009.27738. Epub 2009 Jul 15. Am J Clin Nutr. 2009. PMID: 19605566 Free PMC article.
An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort.
Geng X, Irvin MR, Hidalgo B, Aslibekyan S, Srinivasasainagendra V, An P, Frazier-Wood AC, Tiwari HK, Dave T, Ryan K, Ordovas JM, Straka RJ, Feitosa MF, Hopkins PN, Borecki I, Province MA, Mitchell BD, Arnett DK, Zhi D. Geng X, et al. Among authors: an p. J Lipid Res. 2018 Apr;59(4):722-729. doi: 10.1194/jlr.P080333. Epub 2018 Feb 20. J Lipid Res. 2018. PMID: 29463568 Free PMC article.
In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) therapy in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) cohort using an exome-wide sequencing-based association stud …
In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) …
Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response.
An P, Straka RJ, Pollin TI, Feitosa MF, Wojczynski MK, Daw EW, O'Connell JR, Gibson Q, Ryan KA, Hopkins PN, Tsai MY, Lai CQ, Province MA, Ordovas JM, Shuldiner AR, Arnett DK, Borecki IB. An P, et al. Hum Genet. 2014 Jul;133(7):919-30. doi: 10.1007/s00439-014-1435-3. Epub 2014 Mar 7. Hum Genet. 2014. PMID: 24604477 Free PMC article.
The best association signal was found in a tri-genic region at RHOQ-PIGF-CRIPT for baseline NHDL (lead SNP rs6544903, discovery p = 7e-7, MAF = 2 %; validation p = 6e-4 at 0.1 kb upstream neighboring SNP rs3768725, and 5e-4 at 0.7 kb downstream neighboring SNP rs673 …
The best association signal was found in a tri-genic region at RHOQ-PIGF-CRIPT for baseline NHDL (lead SNP rs6544903, discovery p = 7 …
An Exome-Wide Sequencing Study of the GOLDN Cohort Reveals Novel Associations of Coding Variants and Fasting Plasma Lipids.
Geng X, Irvin MR, Hidalgo B, Aslibekyan S, Srinivasasainagendra V, An P, Frazier-Wood AC, Tiwari HK, Dave T, Ryan K, Ordovas JM, Straka RJ, Feitosa MF, Hopkins PN, Borecki I, Province MA, Mitchell BD, Arnett DK, Zhi D. Geng X, et al. Among authors: an p. Front Genet. 2019 Feb 26;10:158. doi: 10.3389/fgene.2019.00158. eCollection 2019. Front Genet. 2019. PMID: 30863429 Free PMC article.
In single variant tests, one variant (rs11171663 in ITGA7) was associated with fasting triglyceride levels (P = 7.66E-08), explaining approximately 3.2% of the total trait variance. In gene-based tests, we found statistically significant associations between ITGA7 (P …
In single variant tests, one variant (rs11171663 in ITGA7) was associated with fasting triglyceride levels (P = 7.66E-08), explaining …
983 results