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Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration.
Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S; CHARTER Group. Croteau D, et al. Among authors: mccutchan ja. J Antimicrob Chemother. 2013 Mar;68(3):684-9. doi: 10.1093/jac/dks441. Epub 2012 Nov 9. J Antimicrob Chemother. 2013. PMID: 23143899 Free PMC article.
Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy.
Langford TD, Letendre SL, Marcotte TD, Ellis RJ, McCutchan JA, Grant I, Mallory ME, Hansen LA, Archibald S, Jernigan T, Masliah E; HNRC Group. Langford TD, et al. Among authors: mccutchan ja. AIDS. 2002 May 3;16(7):1019-29. doi: 10.1097/00002030-200205030-00008. AIDS. 2002. PMID: 11953468 Free PMC article.
Patterns of selective neuronal damage in methamphetamine-user AIDS patients.
Langford D, Adame A, Grigorian A, Grant I, McCutchan JA, Ellis RJ, Marcotte TD, Masliah E; HIV Neurobehavioral Research Center Group. Langford D, et al. Among authors: mccutchan ja. J Acquir Immune Defic Syndr. 2003 Dec 15;34(5):467-74. doi: 10.1097/00126334-200312150-00004. J Acquir Immune Defic Syndr. 2003. PMID: 14657756
349 results