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Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration.
Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S; CHARTER Group. Croteau D, et al. Among authors: gelman bb. J Antimicrob Chemother. 2013 Mar;68(3):684-9. doi: 10.1093/jac/dks441. Epub 2012 Nov 9. J Antimicrob Chemother. 2013. PMID: 23143899 Free PMC article.
Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV.
Woods SP, Rippeth JD, Frol AB, Levy JK, Ryan E, Soukup VM, Hinkin CH, Lazzaretto D, Cherner M, Marcotte TD, Gelman BB, Morgello S, Singer EJ, Grant I, Heaton RK. Woods SP, et al. Among authors: gelman bb. J Clin Exp Neuropsychol. 2004 Sep;26(6):759-78. doi: 10.1080/13803390490509565. J Clin Exp Neuropsychol. 2004. PMID: 15370374
The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system.
Letendre SL, Marquie-Beck J, Ellis RJ, Woods SP, Best B, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson D, Alexander TJ, Durelle J, Heaton R, Grant I; CHARTER Group. Letendre SL, et al. Among authors: gelman bb. J Neuroimmune Pharmacol. 2007 Mar;2(1):120-7. doi: 10.1007/s11481-006-9054-y. Epub 2007 Jan 3. J Neuroimmune Pharmacol. 2007. PMID: 18040835
Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system.
Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D, Grant I, Ellis RJ; CHARTER Group. Letendre S, et al. Among authors: gelman bb. Arch Neurol. 2008 Jan;65(1):65-70. doi: 10.1001/archneurol.2007.31. Arch Neurol. 2008. PMID: 18195140 Free PMC article.
Low atazanavir concentrations in cerebrospinal fluid.
Best BM, Letendre SL, Brigid E, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Ellis R, Capparelli EV, Grant I; CHARTER Group. Best BM, et al. Among authors: gelman bb. AIDS. 2009 Jan 2;23(1):83-7. doi: 10.1097/QAD.0b013e328317a702. AIDS. 2009. PMID: 19050389 Free PMC article. Clinical Trial.
Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy.
Ellis RJ, Marquie-Beck J, Delaney P, Alexander T, Clifford DB, McArthur JC, Simpson DM, Ake C, Collier AC, Gelman BB, McCutchan JA, Morgello S, Grant I; CHARTER Group. Ellis RJ, et al. Among authors: gelman bb. Ann Neurol. 2008 Nov;64(5):566-72. doi: 10.1002/ana.21484. Ann Neurol. 2008. PMID: 19067367 Free PMC article.
Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study.
Ellis RJ, Rosario D, Clifford DB, McArthur JC, Simpson D, Alexander T, Gelman BB, Vaida F, Collier A, Marra CM, Ances B, Atkinson JH, Dworkin RH, Morgello S, Grant I; CHARTER Study Group. Ellis RJ, et al. Among authors: gelman bb. Arch Neurol. 2010 May;67(5):552-8. doi: 10.1001/archneurol.2010.76. Arch Neurol. 2010. PMID: 20457954 Free PMC article.
Association of self-reported painful symptoms with clinical and neurophysiologic signs in HIV-associated sensory neuropathy.
Robinson-Papp J, Morgello S, Vaida F, Fitzsimons C, Simpson DM, Elliott KJ, Al-Lozi M, Gelman BB, Clifford D, Marra CM, McCutchan JA, Atkinson JH, Dworkin RH, Grant I, Ellis R. Robinson-Papp J, et al. Among authors: gelman bb. Pain. 2010 Dec;151(3):732-736. doi: 10.1016/j.pain.2010.08.045. Epub 2010 Sep 20. Pain. 2010. PMID: 20851521 Free PMC article.
Efavirenz concentrations in CSF exceed IC50 for wild-type HIV.
Best BM, Koopmans PP, Letendre SL, Capparelli EV, Rossi SS, Clifford DB, Collier AC, Gelman BB, Mbeo G, McCutchan JA, Simpson DM, Haubrich R, Ellis R, Grant I; CHARTER Group. Best BM, et al. Among authors: gelman bb. J Antimicrob Chemother. 2011 Feb;66(2):354-7. doi: 10.1093/jac/dkq434. Epub 2010 Nov 23. J Antimicrob Chemother. 2011. PMID: 21098541 Free PMC article.
171 results