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Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration.
Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S; CHARTER Group. Croteau D, et al. J Antimicrob Chemother. 2013 Mar;68(3):684-9. doi: 10.1093/jac/dks441. Epub 2012 Nov 9. J Antimicrob Chemother. 2013. PMID: 23143899 Free PMC article.
Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1.
Croteau D, Letendre S, Best BM, Ellis RJ, Breidinger S, Clifford D, Collier A, Gelman B, Marra C, Mbeo G, McCutchan A, Morgello S, Simpson D, Way L, Vaida F, Ueland S, Capparelli E, Grant I; CHARTER Group. Croteau D, et al. Antimicrob Agents Chemother. 2010 Dec;54(12):5156-60. doi: 10.1128/AAC.00507-10. Epub 2010 Sep 27. Antimicrob Agents Chemother. 2010. PMID: 20876368 Free PMC article.
Therapeutic amprenavir concentrations in cerebrospinal fluid.
Croteau D, Letendre S, Best BM, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Way L, Capparelli E, Grant I; CHARTER Group. Croteau D, et al. Antimicrob Agents Chemother. 2012 Apr;56(4):1985-9. doi: 10.1128/AAC.05098-11. Epub 2012 Jan 30. Antimicrob Agents Chemother. 2012. PMID: 22290964 Free PMC article.
Etravirine in CSF is highly protein bound.
Nguyen A, Rossi S, Croteau D, Best BM, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Ellis RJ, Grant I, Capparelli E, Letendre S; CHARTER Group. Nguyen A, et al. Among authors: croteau d. J Antimicrob Chemother. 2013 May;68(5):1161-8. doi: 10.1093/jac/dks517. Epub 2013 Jan 20. J Antimicrob Chemother. 2013. PMID: 23335197 Free PMC article.
Increases in brain white matter abnormalities and subcortical gray matter are linked to CD4 recovery in HIV infection.
Fennema-Notestine C, Ellis RJ, Archibald SL, Jernigan TL, Letendre SL, Notestine RJ, Taylor MJ, Theilmann RJ, Julaton MD, Croteau DJ, Wolfson T, Heaton RK, Gamst AC, Franklin DR Jr, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I; CHARTER Group. Fennema-Notestine C, et al. Among authors: croteau dj. J Neurovirol. 2013 Aug;19(4):393-401. doi: 10.1007/s13365-013-0185-7. Epub 2013 Jul 10. J Neurovirol. 2013. PMID: 23838849 Free PMC article.
Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients.
Ma Q, Vaida F, Wong J, Sanders CA, Kao YT, Croteau D, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, Morgello S, Simpson DM, Heaton RK, Grant I, Letendre SL; CHARTER Group. Ma Q, et al. Among authors: croteau d. J Neurovirol. 2016 Apr;22(2):170-8. doi: 10.1007/s13365-015-0382-7. Epub 2015 Sep 25. J Neurovirol. 2016. PMID: 26407716 Free PMC article.
221 results