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Page 1
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.
Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN. Thorneloe KS, et al. Among authors: townsley mi. Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276. Sci Transl Med. 2012. PMID: 23136043
TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs.
Hamanaka K, Jian MY, Weber DS, Alvarez DF, Townsley MI, Al-Mehdi AB, King JA, Liedtke W, Parker JC. Hamanaka K, et al. Among authors: townsley mi. Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L923-32. doi: 10.1152/ajplung.00221.2007. Epub 2007 Jul 27. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 17660328 Free article.
Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.
Wu S, Jian MY, Xu YC, Zhou C, Al-Mehdi AB, Liedtke W, Shin HS, Townsley MI. Wu S, et al. Among authors: townsley mi. Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L650-7. doi: 10.1152/ajplung.00015.2009. Epub 2009 Jul 17. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 19617313 Free PMC article.
TRPV4 channels augment macrophage activation and ventilator-induced lung injury.
Hamanaka K, Jian MY, Townsley MI, King JA, Liedtke W, Weber DS, Eyal FG, Clapp MM, Parker JC. Hamanaka K, et al. Among authors: townsley mi. Am J Physiol Lung Cell Mol Physiol. 2010 Sep;299(3):L353-62. doi: 10.1152/ajplung.00315.2009. Epub 2010 Jun 18. Am J Physiol Lung Cell Mol Physiol. 2010. PMID: 20562229 Free PMC article.
Role of MMP2 and MMP9 in TRPV4-induced lung injury.
Villalta PC, Rocic P, Townsley MI. Villalta PC, et al. Among authors: townsley mi. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 15;307(8):L652-9. doi: 10.1152/ajplung.00113.2014. Epub 2014 Aug 22. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 25150065 Free PMC article.
89 results