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Preclinical research in Rett syndrome: setting the foundation for translational success.
Katz DM, Berger-Sweeney JE, Eubanks JH, Justice MJ, Neul JL, Pozzo-Miller L, Blue ME, Christian D, Crawley JN, Giustetto M, Guy J, Howell CJ, Kron M, Nelson SB, Samaco RC, Schaevitz LR, St Hillaire-Clarke C, Young JL, Zoghbi HY, Mamounas LA. Katz DM, et al. Among authors: zoghbi hy. Dis Model Mech. 2012 Nov;5(6):733-45. doi: 10.1242/dmm.011007. Dis Model Mech. 2012. PMID: 23115203 Free PMC article. Review.
Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities.
Samaco RC, Mandel-Brehm C, Chao HT, Ward CS, Fyffe-Maricich SL, Ren J, Hyland K, Thaller C, Maricich SM, Humphreys P, Greer JJ, Percy A, Glaze DG, Zoghbi HY, Neul JL. Samaco RC, et al. Among authors: zoghbi hy. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21966-71. doi: 10.1073/pnas.0912257106. Epub 2009 Dec 9. Proc Natl Acad Sci U S A. 2009. PMID: 20007372 Free PMC article.
Adult neural function requires MeCP2.
McGraw CM, Samaco RC, Zoghbi HY. McGraw CM, et al. Among authors: zoghbi hy. Science. 2011 Jul 8;333(6039):186. doi: 10.1126/science.1206593. Epub 2011 Jun 2. Science. 2011. PMID: 21636743 Free PMC article.
405 results