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Preclinical research in Rett syndrome: setting the foundation for translational success.
Katz DM, Berger-Sweeney JE, Eubanks JH, Justice MJ, Neul JL, Pozzo-Miller L, Blue ME, Christian D, Crawley JN, Giustetto M, Guy J, Howell CJ, Kron M, Nelson SB, Samaco RC, Schaevitz LR, St Hillaire-Clarke C, Young JL, Zoghbi HY, Mamounas LA. Katz DM, et al. Among authors: samaco rc. Dis Model Mech. 2012 Nov;5(6):733-45. doi: 10.1242/dmm.011007. Dis Model Mech. 2012. PMID: 23115203 Free PMC article. Review.
Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities.
Samaco RC, Mandel-Brehm C, Chao HT, Ward CS, Fyffe-Maricich SL, Ren J, Hyland K, Thaller C, Maricich SM, Humphreys P, Greer JJ, Percy A, Glaze DG, Zoghbi HY, Neul JL. Samaco RC, et al. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21966-71. doi: 10.1073/pnas.0912257106. Epub 2009 Dec 9. Proc Natl Acad Sci U S A. 2009. PMID: 20007372 Free PMC article.
Complexities of Rett syndrome and MeCP2.
Samaco RC, Neul JL. Samaco RC, et al. J Neurosci. 2011 Jun 1;31(22):7951-9. doi: 10.1523/JNEUROSCI.0169-11.2011. J Neurosci. 2011. PMID: 21632916 Free PMC article. Review. No abstract available.
Adult neural function requires MeCP2.
McGraw CM, Samaco RC, Zoghbi HY. McGraw CM, et al. Among authors: samaco rc. Science. 2011 Jul 8;333(6039):186. doi: 10.1126/science.1206593. Epub 2011 Jun 2. Science. 2011. PMID: 21636743 Free PMC article.
Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome.
Veeraragavan S, Wan YW, Connolly DR, Hamilton SM, Ward CS, Soriano S, Pitcher MR, McGraw CM, Huang SG, Green JR, Yuva LA, Liang AJ, Neul JL, Yasui DH, LaSalle JM, Liu Z, Paylor R, Samaco RC. Veeraragavan S, et al. Among authors: samaco rc. Hum Mol Genet. 2016 Aug 1;25(15):3284-3302. doi: 10.1093/hmg/ddw178. Epub 2016 Jun 30. Hum Mol Genet. 2016. PMID: 27365498 Free PMC article.
40 results