Laird MW - Search Results

1

Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodies.

Feeney L, Carvalhal V, Yu XC, Chan B, Michels DA, Wang YJ, Shen A, Ressl J, Dusel B, Laird MW. Feeney L, et al. Among authors: laird mw. Biotechnol Bioeng. 2013 Apr;110(4):1087-97. doi: 10.1002/bit.24759. Epub 2013 Feb 15. Biotechnol Bioeng. 2013. PMID: 23108857

2

Identification and prevention of antibody disulfide bond reduction during cell culture manufacturing.

Trexler-Schmidt M, Sargis S, Chiu J, Sze-Khoo S, Mun M, Kao YH, Laird MW. Trexler-Schmidt M, et al. Among authors: laird mw. Biotechnol Bioeng. 2010 Jun 15;106(3):452-61. doi: 10.1002/bit.22699. Biotechnol Bioeng. 2010. PMID: 20178122

3

Characterization of a monoclonal antibody cell culture production process using a quality by design approach.

Horvath B, Mun M, Laird MW. Horvath B, et al. Among authors: laird mw. Mol Biotechnol. 2010 Jul;45(3):203-6. doi: 10.1007/s12033-010-9267-4. Mol Biotechnol. 2010. PMID: 20300882

4

Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cells.

Guo D, Gao A, Michels DA, Feeney L, Eng M, Chan B, Laird MW, Zhang B, Yu XC, Joly J, Snedecor B, Shen A. Guo D, et al. Among authors: laird mw. Biotechnol Bioeng. 2010 Sep 1;107(1):163-71. doi: 10.1002/bit.22780. Biotechnol Bioeng. 2010. PMID: 20506532

5

Mechanism of antibody reduction in cell culture production processes.

Kao YH, Hewitt DP, Trexler-Schmidt M, Laird MW. Kao YH, et al. Among authors: laird mw. Biotechnol Bioeng. 2010 Nov 1;107(4):622-32. doi: 10.1002/bit.22848. Biotechnol Bioeng. 2010. PMID: 20589844

6

Use of disposable reactors to generate inoculum cultures for E. coli production fermentations.

Mahajan E, Matthews T, Hamilton R, Laird MW. Mahajan E, et al. Among authors: laird mw. Biotechnol Prog. 2010 Jul-Aug;26(4):1200-3. doi: 10.1002/btpr.414. Biotechnol Prog. 2010. PMID: 20730774

7

Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture.

Koterba KL, Borgschulte T, Laird MW. Koterba KL, et al. Among authors: laird mw. J Biotechnol. 2012 Jan;157(1):261-7. doi: 10.1016/j.jbiotec.2011.11.009. Epub 2011 Nov 25. J Biotechnol. 2012. PMID: 22138638

8

Strain engineering to prevent norleucine incorporation during recombinant protein production in Escherichia coli.

Veeravalli K, Laird MW, Fedesco M, Zhang Y, Yu XC. Veeravalli K, et al. Among authors: laird mw. Biotechnol Prog. 2015 Jan-Feb;31(1):204-11. doi: 10.1002/btpr.1999. Epub 2014 Oct 21. Biotechnol Prog. 2015. PMID: 25315437

9

Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid.

Mun M, Khoo S, Do Minh A, Dvornicky J, Trexler-Schmidt M, Kao YH, Laird MW. Mun M, et al. Among authors: laird mw. Biotechnol Bioeng. 2015 Apr;112(4):734-42. doi: 10.1002/bit.25495. Epub 2014 Dec 23. Biotechnol Bioeng. 2015. PMID: 25384896

10

Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells.

Hu Z, Tang D, Misaghi S, Jiang G, Yu C, Yim M, Shaw D, Snedecor B, Laird MW, Shen A. Hu Z, et al. Among authors: laird mw. Biotechnol Prog. 2017 May;33(3):786-794. doi: 10.1002/btpr.2444. Epub 2017 Mar 24. Biotechnol Prog. 2017. PMID: 28188688

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