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Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.
Jiang H, Zeng J, Li W, Bifano M, Gu H, Titsch C, Easter J, Burrell R, Kandoussi H, Aubry AF, Arnold ME. Jiang H, et al. Among authors: titsch c. Anal Chem. 2012 Nov 20;84(22):10031-7. doi: 10.1021/ac3024558. Epub 2012 Nov 6. Anal Chem. 2012. PMID: 23106420
Overcoming interference with the detection of a stable isotopically labeled microtracer in the evaluation of beclabuvir absolute bioavailability using a concomitant microtracer approach.
Jiang H, Titsch C, Zeng J, Jones B, Joyce P, Gandhi Y, Turley W, Burrell R, Aubry AF, Arnold ME. Jiang H, et al. Among authors: titsch c. J Pharm Biomed Anal. 2017 Sep 5;143:9-16. doi: 10.1016/j.jpba.2017.04.030. Epub 2017 May 17. J Pharm Biomed Anal. 2017. PMID: 28544885
Development and characterization of a pre-treatment procedure to eliminate human monoclonal antibody therapeutic drug and matrix interference in cell-based functional neutralizing antibody assays.
Xu W, Jiang H, Titsch C, Haulenbeek JR, Pillutla RC, Aubry AF, DeSilva BS, Arnold ME, Zeng J, Dodge RW. Xu W, et al. Among authors: titsch c. J Immunol Methods. 2015 Jan;416:94-104. doi: 10.1016/j.jim.2014.11.005. Epub 2014 Nov 8. J Immunol Methods. 2015. PMID: 25445325
Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.
Shen H, Liu T, Jiang H, Titsch C, Taylor K, Kandoussi H, Qiu X, Chen C, Sukrutharaj S, Kuit K, Mintier G, Krishnamurthy P, Fancher RM, Zeng J, Rodrigues AD, Marathe P, Lai Y. Shen H, et al. Among authors: titsch c. Drug Metab Dispos. 2016 Feb;44(2):238-49. doi: 10.1124/dmd.115.066852. Epub 2015 Nov 25. Drug Metab Dispos. 2016. PMID: 26608080
12 results