Easter J - Search Results

1

Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.

Jiang H, Zeng J, Li W, Bifano M, Gu H, Titsch C, Easter J, Burrell R, Kandoussi H, Aubry AF, Arnold ME. Jiang H, et al. Among authors: easter j. Anal Chem. 2012 Nov 20;84(22):10031-7. doi: 10.1021/ac3024558. Epub 2012 Nov 6. Anal Chem. 2012. PMID: 23106420

2

Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies.

Gu H, Wang J, Aubry AF, Jiang H, Zeng J, Easter J, Wang JS, Dockens R, Bifano M, Burrell R, Arnold ME. Gu H, et al. Among authors: easter j. Anal Chem. 2012 Jun 5;84(11):4844-50. doi: 10.1021/ac300442v. Epub 2012 May 10. Anal Chem. 2012. PMID: 22540405

3

An alternative and robust synthesis of [(13) C4 ]Baraclude® (entecavir).

Easter JA, Burrell RC, Bonacorsi SJ Jr. Easter JA, et al. J Labelled Comp Radiopharm. 2013 Oct;56(12):632-6. doi: 10.1002/jlcr.3064. Epub 2013 Jul 16. J Labelled Comp Radiopharm. 2013. PMID: 24285240

4

Synthesis of isotopically labeled daclatasvir for use in human clinical studies.

Easter JA, Burrell RC, Bonacorsi SJ Jr. Easter JA, et al. J Labelled Comp Radiopharm. 2016 Apr;59(4):164-70. doi: 10.1002/jlcr.3386. Epub 2016 Mar 10. J Labelled Comp Radiopharm. 2016. PMID: 26968868

5

Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma.

Jiang H, Kandoussi H, Zeng J, Wang J, Demers R, Eley T, He B, Burrell R, Easter J, Kadiyala P, Pursley J, Cojocaru L, Baker C, Ryan J, Aubry AF, Arnold ME. Jiang H, et al. Among authors: easter j. J Pharm Biomed Anal. 2015 Mar 25;107:409-18. doi: 10.1016/j.jpba.2015.01.027. Epub 2015 Jan 20. J Pharm Biomed Anal. 2015. PMID: 25676854

6

LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions.

Santockyte R, Kandoussi H, Chen W, Zheng N, Venkatarangan L, Gan J, Shen H, Bonacorsi SJ, Easter J, Burrell R, Zhang YJ, Zeng J. Santockyte R, et al. Among authors: easter j. Bioanalysis. 2018 Sep 1;10(18):1473-1485. doi: 10.4155/bio-2018-0170. Epub 2018 Sep 14. Bioanalysis. 2018. PMID: 30215261

7

Challenges in accurate quantitation of lysophosphatidic acids in human biofluids.

Onorato JM, Shipkova P, Minnich A, Aubry AF, Easter J, Tymiak A. Onorato JM, et al. Among authors: easter j. J Lipid Res. 2014 Aug;55(8):1784-96. doi: 10.1194/jlr.D050070. Epub 2014 May 28. J Lipid Res. 2014. PMID: 24872406 Free PMC article. Clinical Trial.

8

Synthesis of carbon-14 and stable isotope labeled Avagacestat: a novel gamma secretase inhibitor for the treatment of Alzheimer's disease.

Burrell RC, Easter JA, Cassidy MP, Gillman KW, Olson RE, Bonacorsi SJ. Burrell RC, et al. Among authors: easter ja. J Labelled Comp Radiopharm. 2014 Aug;57(10):600-5. doi: 10.1002/jlcr.3224. Epub 2014 Sep 5. J Labelled Comp Radiopharm. 2014. PMID: 25196195

9

Synthesis of tritium labeled 30-KDa PEG and conjugation to form [³ H]Pegbelfermin.

Easter JA, Tian Y, Burrell RC, Hong Y, Bonacorsi SJ Jr. Easter JA, et al. J Labelled Comp Radiopharm. 2021 Oct;64(12):477-481. doi: 10.1002/jlcr.3940. Epub 2021 Aug 23. J Labelled Comp Radiopharm. 2021. PMID: 34386991

10

Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans.

Gong J, Eley T, He B, Arora V, Philip T, Jiang H, Easter J, Humphreys WG, Iyer RA, Li W. Gong J, et al. Among authors: easter j. Xenobiotica. 2016;46(1):52-64. doi: 10.3109/00498254.2015.1048487. Epub 2015 Jul 7. Xenobiotica. 2016. PMID: 26153443 Clinical Trial.

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