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Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.
Garcia LC, Donadío LG, Mann E, Kolusheva S, Kedei N, Lewin NE, Hill CS, Kelsey JS, Yang J, Esch TE, Santos M, Peach ML, Kelley JA, Blumberg PM, Jelinek R, Marquez VE, Comin MJ. Garcia LC, et al. Among authors: kedei n. Bioorg Med Chem. 2014 Jun 15;22(12):3123-40. doi: 10.1016/j.bmc.2014.04.024. Epub 2014 Apr 20. Bioorg Med Chem. 2014. PMID: 24794745 Free PMC article.
Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.
Malolanarasimhan K, Kedei N, Sigano DM, Kelley JA, Lai CC, Lewin NE, Surawski RJ, Pavlyukovets VA, Garfield SH, Wincovitch S, Blumberg PM, Marquez VE. Malolanarasimhan K, et al. Among authors: kedei n. J Med Chem. 2007 Mar 8;50(5):962-78. doi: 10.1021/jm061289j. Epub 2007 Feb 7. J Med Chem. 2007. PMID: 17284021
Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths.
Comin MJ, Czifra G, Kedei N, Telek A, Lewin NE, Kolusheva S, Velasquez JF, Kobylarz R, Jelinek R, Blumberg PM, Marquez VE. Comin MJ, et al. Among authors: kedei n. J Med Chem. 2009 May 28;52(10):3274-83. doi: 10.1021/jm900186m. J Med Chem. 2009. PMID: 19379015 Free PMC article.
Charge density influences C1 domain ligand affinity and membrane interactions.
Kelsey JS, Geczy T, Lewin NE, Kedei N, Hill CS, Selezneva JS, Valle CJ, Woo W, Gorshkova I, Blumberg PM. Kelsey JS, et al. Among authors: kedei n. Chembiochem. 2014 May 26;15(8):1131-1144. doi: 10.1002/cbic.201400041. Epub 2014 Apr 28. Chembiochem. 2014. PMID: 24777910 Free PMC article.
77 results