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Page 1
Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.
McComas C, Cohen J, Huselton C, Marella M, Melenski E, Mugford C, Slayden O, Winneker R, Wrobel J, Yudt MR, Fensome A. McComas C, et al. Among authors: mugford c. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7119-22. doi: 10.1016/j.bmcl.2012.09.077. Epub 2012 Sep 29. Bioorg Med Chem Lett. 2012. PMID: 23079530
Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348).
Fensome A, Adams WR, Adams AL, Berrodin TJ, Cohen J, Huselton C, Illenberger A, Kern JC, Hudak VA, Marella MA, Melenski EG, McComas CC, Mugford CA, Slayden OD, Yudt M, Zhang Z, Zhang P, Zhu Y, Winneker RC, Wrobel JE. Fensome A, et al. Among authors: mugford ca. J Med Chem. 2008 Mar 27;51(6):1861-73. doi: 10.1021/jm701080t. Epub 2008 Mar 5. J Med Chem. 2008. PMID: 18318463
1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors.
Zhang P, Terefenko EA, Bray J, Deecher D, Fensome A, Harrison J, Kim C, Koury E, Mark L, McComas CC, Mugford CA, Trybulski EJ, Vu AT, Whiteside GT, Mahaney PE. Zhang P, et al. Among authors: mugford ca. J Med Chem. 2009 Sep 24;52(18):5703-11. doi: 10.1021/jm900888c. J Med Chem. 2009. PMID: 19722525
Discovery of WAY-260022, a Potent and Selective Inhibitor of the Norepinephrine Transporter.
Gavrin LK, Mahaney PE, Jenkins D, Nogle LM, Mugford CA, Huselton C, Leiter J, Johnston GH, Bray JA, Burroughs KD, Cosmi SA, Alfinito P, Ho DM, Deecher DC, Trybulski EJ. Gavrin LK, et al. Among authors: mugford ca. ACS Med Chem Lett. 2010 Mar 25;1(3):91-5. doi: 10.1021/ml100009p. eCollection 2010 Jun 10. ACS Med Chem Lett. 2010. PMID: 24900182 Free PMC article.
Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors.
Mahaney PE, Gavrin LK, Trybulski EJ, Stack GP, Vu TA, Cohn ST, Ye F, Belardi JK, Santilli AA, Sabatucci JP, Leiter J, Johnston GH, Bray JA, Burroughs KD, Cosmi SA, Leventhal L, Koury EJ, Zhang Y, Mugford CA, Ho DM, Rosenzweig-Lipson SJ, Platt B, Smith VA, Deecher DC. Mahaney PE, et al. Among authors: mugford ca. J Med Chem. 2008 Jul 10;51(13):4038-49. doi: 10.1021/jm8002262. Epub 2008 Jun 17. J Med Chem. 2008. PMID: 18557608
Sex-dependent metabolism of xenobiotics.
Mugford CA, Kedderis GL. Mugford CA, et al. Drug Metab Rev. 1998 Aug;30(3):441-98. doi: 10.3109/03602539808996322. Drug Metab Rev. 1998. PMID: 9710703 Review.
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