Schofield CJ - Search Results

1

Mechanisms of human histone and nucleic acid demethylases.

Walport LJ, Hopkinson RJ, Schofield CJ. Walport LJ, et al. Among authors: schofield cj. Curr Opin Chem Biol. 2012 Dec;16(5-6):525-34. doi: 10.1016/j.cbpa.2012.09.015. Epub 2012 Oct 10. Curr Opin Chem Biol. 2012. PMID: 23063108 Review.

2

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.

Schofield CJ, Zhang Z. Schofield CJ, et al. Curr Opin Struct Biol. 1999 Dec;9(6):722-31. doi: 10.1016/s0959-440x(99)00036-6. Curr Opin Struct Biol. 1999. PMID: 10607676 Review.

3

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Ng SS, et al. Among authors: schofield cj. Nature. 2007 Jul 5;448(7149):87-91. doi: 10.1038/nature05971. Epub 2007 Jun 24. Nature. 2007. PMID: 17589501

4

Expanding chemical biology of 2-oxoglutarate oxygenases.

Loenarz C, Schofield CJ. Loenarz C, et al. Among authors: schofield cj. Nat Chem Biol. 2008 Mar;4(3):152-6. doi: 10.1038/nchembio0308-152. Nat Chem Biol. 2008. PMID: 18277970

5

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.

Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ. Pollard PJ, et al. Among authors: schofield cj. Biochem J. 2008 Dec 15;416(3):387-94. doi: 10.1042/BJ20081238. Biochem J. 2008. PMID: 18713068

6

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Rose NR, et al. Among authors: schofield cj. J Med Chem. 2008 Nov 27;51(22):7053-6. doi: 10.1021/jm800936s. J Med Chem. 2008. PMID: 18942826

7

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde.

Hopkinson RJ, Hamed RB, Rose NR, Claridge TD, Schofield CJ. Hopkinson RJ, et al. Among authors: schofield cj. Chembiochem. 2010 Mar 1;11(4):506-10. doi: 10.1002/cbic.200900713. Chembiochem. 2010. PMID: 20095001 No abstract available.

8

Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry.

Mackeen MM, Kramer HB, Chang KH, Coleman ML, Hopkinson RJ, Schofield CJ, Kessler BM. Mackeen MM, et al. Among authors: schofield cj. J Proteome Res. 2010 Aug 6;9(8):4082-4092. doi: 10.1021/pr100269b. J Proteome Res. 2010. PMID: 20583823 Free PMC article.

9

Studies on the reaction of glutathione and formaldehyde using NMR.

Hopkinson RJ, Barlow PS, Schofield CJ, Claridge TD. Hopkinson RJ, et al. Among authors: schofield cj. Org Biomol Chem. 2010 Nov 7;8(21):4915-20. doi: 10.1039/c0ob00208a. Epub 2010 Aug 24. Org Biomol Chem. 2010. PMID: 20737071

10

Structural studies on human 2-oxoglutarate dependent oxygenases.

McDonough MA, Loenarz C, Chowdhury R, Clifton IJ, Schofield CJ. McDonough MA, et al. Among authors: schofield cj. Curr Opin Struct Biol. 2010 Dec;20(6):659-72. doi: 10.1016/j.sbi.2010.08.006. Epub 2010 Sep 29. Curr Opin Struct Biol. 2010. PMID: 20888218 Review.

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