Egli M - Search Results

1

A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.

Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd RS. Yamanaka K, et al. Among authors: egli m. PLoS One. 2012;7(10):e45032. doi: 10.1371/journal.pone.0045032. Epub 2012 Oct 8. PLoS One. 2012. PMID: 23056190 Free PMC article.

2

Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4.

Irimia A, Zang H, Loukachevitch LV, Eoff RL, Guengerich FP, Egli M. Irimia A, et al. Among authors: egli m. Biochemistry. 2006 May 16;45(19):5949-56. doi: 10.1021/bi052511+. Biochemistry. 2006. PMID: 16681366

3

Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred.

Eoff RL, Irimia A, Egli M, Guengerich FP. Eoff RL, et al. Among authors: egli m. J Biol Chem. 2007 Jan 12;282(2):1456-67. doi: 10.1074/jbc.M609661200. Epub 2006 Nov 14. J Biol Chem. 2007. PMID: 17105728 Free article.

4

Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing.

Eoff RL, Angel KC, Egli M, Guengerich FP. Eoff RL, et al. Among authors: egli m. J Biol Chem. 2007 May 4;282(18):13573-84. doi: 10.1074/jbc.M700656200. Epub 2007 Mar 3. J Biol Chem. 2007. PMID: 17337730 Free article.

Previous work has shown that Sulfolobus solfataricus DNA polymerase Dpo4-catalyzed bypass of O(6)-methylguanine (O(6)-MeG) proceeds largely in an accurate but inefficient manner with a "wobble" base pairing between C and O(6)-MeG (Eoff, R. L., Irimia, A., Egli, M., …

Previous work has shown that Sulfolobus solfataricus DNA polymerase Dpo4-catalyzed bypass of O(6)-methylguanine (O(6)-MeG) proceeds largely …

5

Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4.

Eoff RL, Irimia A, Angel KC, Egli M, Guengerich FP. Eoff RL, et al. Among authors: egli m. J Biol Chem. 2007 Jul 6;282(27):19831-43. doi: 10.1074/jbc.M702290200. Epub 2007 Apr 27. J Biol Chem. 2007. PMID: 17468100 Free article.

6

Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene.

Irimia A, Eoff RL, Pallan PS, Guengerich FP, Egli M. Irimia A, et al. Among authors: egli m. J Biol Chem. 2007 Dec 14;282(50):36421-33. doi: 10.1074/jbc.M707267200. Epub 2007 Oct 18. J Biol Chem. 2007. PMID: 17951245 Free article.

7

Versatility of Y-family Sulfolobus solfataricus DNA polymerase Dpo4 in translesion synthesis past bulky N2-alkylguanine adducts.

Zhang H, Eoff RL, Kozekov ID, Rizzo CJ, Egli M, Guengerich FP. Zhang H, et al. Among authors: egli m. J Biol Chem. 2009 Feb 6;284(6):3563-76. doi: 10.1074/jbc.M807778200. Epub 2008 Dec 4. J Biol Chem. 2009. PMID: 19059910 Free PMC article.

8

A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.

Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M. Pallan PS, et al. Among authors: egli m. Chem Commun (Camb). 2009 Apr 21;(15):2017-9. doi: 10.1039/b822781k. Epub 2009 Feb 26. Chem Commun (Camb). 2009. PMID: 19333476 Free PMC article.

9

Structural and functional analysis of Sulfolobus solfataricus Y-family DNA polymerase Dpo4-catalyzed bypass of the malondialdehyde-deoxyguanosine adduct.

Eoff RL, Stafford JB, Szekely J, Rizzo CJ, Egli M, Guengerich FP, Marnett LJ. Eoff RL, et al. Among authors: egli m. Biochemistry. 2009 Aug 4;48(30):7079-88. doi: 10.1021/bi9003588. Biochemistry. 2009. PMID: 19492857 Free PMC article.

10

Structural and functional elucidation of the mechanism promoting error-prone synthesis by human DNA polymerase kappa opposite the 7,8-dihydro-8-oxo-2'-deoxyguanosine adduct.

Irimia A, Eoff RL, Guengerich FP, Egli M. Irimia A, et al. Among authors: egli m. J Biol Chem. 2009 Aug 14;284(33):22467-22480. doi: 10.1074/jbc.M109.003905. Epub 2009 Jun 19. J Biol Chem. 2009. PMID: 19542228 Free PMC article.

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