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Page 1
Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.
Abel U, Schlüter T, Schulz A, Hambruch E, Steeneck C, Hornberger M, Hoffmann T, Perović-Ottstadt S, Kinzel O, Burnet M, Deuschle U, Kremoser C. Abel U, et al. Among authors: schluter t. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4911-7. doi: 10.1016/j.bmcl.2010.06.084. Epub 2010 Jun 19. Bioorg Med Chem Lett. 2010. PMID: 20638278
Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties.
Kinzel O, Steeneck C, Schlüter T, Schulz A, Gege C, Hahn U, Hambruch E, Hornberger M, Spalwisz A, Frick K, Perović-Ottstadt S, Deuschle U, Burnet M, Kremoser C. Kinzel O, et al. Among authors: schluter t. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53. doi: 10.1016/j.bmcl.2016.05.070. Epub 2016 May 24. Bioorg Med Chem Lett. 2016. PMID: 27268696
Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) mice.
Hambruch E, Miyazaki-Anzai S, Hahn U, Matysik S, Boettcher A, Perović-Ottstadt S, Schlüter T, Kinzel O, Krol HD, Deuschle U, Burnet M, Levi M, Schmitz G, Miyazaki M, Kremoser C. Hambruch E, et al. Among authors: schluter t. J Pharmacol Exp Ther. 2012 Dec;343(3):556-67. doi: 10.1124/jpet.112.196519. Epub 2012 Aug 23. J Pharmacol Exp Ther. 2012. PMID: 22918042 Free PMC article.
Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.
Steeneck C, Gege C, Kinzel O, Albers M, Kleymann G, Schlüter T, Schulz A, Xue X, Cummings MD, Fourie AM, Leonard KA, Scott B, Edwards JP, Hoffmann T, Goldberg SD. Steeneck C, et al. Among authors: schluter t. Bioorg Med Chem Lett. 2020 Jun 15;30(12):127174. doi: 10.1016/j.bmcl.2020.127174. Epub 2020 Apr 7. Bioorg Med Chem Lett. 2020. PMID: 32334912
Identification and biological evaluation of thiazole-based inverse agonists of RORγt.
Gege C, Cummings MD, Albers M, Kinzel O, Kleymann G, Schlüter T, Steeneck C, Nelen MI, Milligan C, Spurlino J, Xue X, Leonard K, Edwards JP, Fourie A, Goldberg SD, Hoffmann T. Gege C, et al. Among authors: schluter t. Bioorg Med Chem Lett. 2018 May 15;28(9):1446-1455. doi: 10.1016/j.bmcl.2018.03.093. Epub 2018 Apr 3. Bioorg Med Chem Lett. 2018. PMID: 29631962
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
Gege C, Albers M, Kinzel O, Kleymann G, Schlüter T, Steeneck C, Hoffmann T, Xue X, Cummings MD, Spurlino J, Milligan C, Fourie AM, Edwards JP, Leonard K, Coe K, Scott B, Pippel D, Goldberg SD. Gege C, et al. Among authors: schluter t. Bioorg Med Chem Lett. 2020 Jun 15;30(12):127205. doi: 10.1016/j.bmcl.2020.127205. Epub 2020 Apr 21. Bioorg Med Chem Lett. 2020. PMID: 32336498
Measurement of the charged-pion polarizability.
Adolph C, Akhunzyanov R, Alexeev MG, Alexeev GD, Amoroso A, Andrieux V, Anosov V, Austregesilo A, Badełek B, Balestra F, Barth J, Baum G, Beck R, Bedfer Y, Berlin A, Bernhard J, Bicker K, Bieling J, Birsa R, Bisplinghoff J, Bodlak M, Boer M, Bordalo P, Bradamante F, Braun C, Bressan A, Büchele M, Burtin E, Capozza L, Chiosso M, Chung SU, Cicuttin A, Colantoni M, Crespo ML, Curiel Q, Dalla Torre S, Dasgupta SS, Dasgupta S, Denisov OY, Dinkelbach AM, Donskov SV, Doshita N, Duic V, Dünnweber W, Dziewiecki M, Efremov A, Elia C, Eversheim PD, Eyrich W, Faessler M, Ferrero A, Filin A, Finger M Jr, Finger M, Fischer H, Franco C, du Fresne von Hohenesche N, Friedrich JM, Frolov V, Gautheron F, Gavrichtchouk OP, Gerassimov S, Geyer R, Gnesi I, Gobbo B, Goertz S, Gorzellik M, Grabmüller S, Grasso A, Grube B, Grussenmeyer T, Guskov A, Guthörl T, Haas F, von Harrach D, Hahne D, Hashimoto R, Heinsius FH, Herrmann F, Hinterberger F, Höppner Ch, Horikawa N, d'Hose N, Huber S, Ishimoto S, Ivanov A, Ivanshin Y, Iwata T, Jahn R, Jary V, Jasinski P, Jörg P, Joosten R, Kabuss E, Ketzer B, Khaustov GV, Khokhlov YA, Kisselev Y, Klein F, Klimaszewski K, Koivuniemi JH, Kolosov VN, Kondo K, Königsmann K, … See abstract for full author list ➔ Adolph C, et al. Among authors: schluter t. Phys Rev Lett. 2015 Feb 13;114(6):062002. doi: 10.1103/PhysRevLett.114.062002. Epub 2015 Feb 10. Phys Rev Lett. 2015. PMID: 25723208 Free article.
78 results