Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia.
Xie C, Cao X, Chen X, Wang D, Zhang WK, Sun Y, Hu W, Zhou Z, Wang Y, Huang P.
Xie C, et al.
FASEB J. 2016 Apr;30(4):1579-89. doi: 10.1096/fj.15-283002. Epub 2015 Dec 18.
FASEB J. 2016.
PMID: 26683699
Free PMC article.
Our findings uncover a previously unrecognized mechanism underlying CFTR involvement in epithelial RVD and suggest that the mechanosensitivity of G551D CFTR might underlie the mild phenotypes resulting from this mutation.-Xie, C., Cao, X., Chen, X, Wang, D., Zhang, …
Our findings uncover a previously unrecognized mechanism underlying CFTR involvement in epithelial RVD and suggest that the mechanosensitivi …