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DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks.
Mosbech A, Gibbs-Seymour I, Kagias K, Thorslund T, Beli P, Povlsen L, Nielsen SV, Smedegaard S, Sedgwick G, Lukas C, Hartmann-Petersen R, Lukas J, Choudhary C, Pocock R, Bekker-Jensen S, Mailand N. Mosbech A, et al. Among authors: sedgwick g. Nat Struct Mol Biol. 2012 Nov;19(11):1084-92. doi: 10.1038/nsmb.2395. Epub 2012 Oct 7. Nat Struct Mol Biol. 2012. PMID: 23042605
Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.
Townsend K, Mason H, Blackford AN, Miller ES, Chapman JR, Sedgwick GG, Barone G, Turnell AS, Stewart GS. Townsend K, et al. Among authors: sedgwick gg. J Biol Chem. 2009 Dec 4;284(49):33939-48. doi: 10.1074/jbc.M109.009191. Epub 2009 Oct 13. J Biol Chem. 2009. PMID: 19826003 Free PMC article.
Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.
Forrester NA, Patel RN, Speiseder T, Groitl P, Sedgwick GG, Shimwell NJ, Seed RI, Catnaigh PÓ, McCabe CJ, Stewart GS, Dobner T, Grand RJ, Martin A, Turnell AS. Forrester NA, et al. Among authors: sedgwick gg. J Virol. 2012 Mar;86(6):3167-79. doi: 10.1128/JVI.06583-11. Epub 2011 Dec 28. J Virol. 2012. PMID: 22205733 Free PMC article.
28 results