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Page 1
Synthesis and SAR of geminal substitutions at the C5' carbosugar position of pyrimidine-derived HCV inhibitors.
Verma VA, Rossman R, Bennett F, Chen L, Gavalas S, Girijavallabhan V, Huang Y, Kim SH, Kosinski A, Pinto P, Rizvi R, Shankar B, Tong L, Velazquez F, Venkatraman S, Kozlowski J, MacCoss M, Kwong CD, Bansal N, Kezar HS 3rd, Reynolds RC, Maddry JA, Ananthan S, Secrist JA 3rd, Li C, Chase R, Curry S, Huang HC, Tong X, Njoroge FG, Arasappan A. Verma VA, et al. Among authors: tong l, tong x. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6967-73. doi: 10.1016/j.bmcl.2012.08.111. Epub 2012 Sep 7. Bioorg Med Chem Lett. 2012. PMID: 23036957
Toward second generation hepatitis C virus NS3 serine protease inhibitors: discovery of novel P4 modified analogues with improved potency and pharmacokinetic profile.
Arasappan A, Padilla AI, Jao E, Bennett F, Bogen SL, Chen KX, Pike RE, Sannigrahi M, Soares J, Venkatraman S, Vibulbhan B, Saksena AK, Girijavallabhan V, Tong X, Cheng KC, Njoroge FG. Arasappan A, et al. Among authors: tong x. J Med Chem. 2009 May 14;52(9):2806-17. doi: 10.1021/jm801616e. J Med Chem. 2009. PMID: 19371095
Toward the back-up of boceprevir (SCH 503034): discovery of new extended P4-capped ketoamide inhibitors of hepatitis C virus NS3 serine protease with improved potency and pharmacokinetic profiles.
Bogen SL, Pan W, Ruan S, Nair LG, Arasappan A, Bennett F, Chen KX, Jao E, Venkatraman S, Vibulbhan B, Liu R, Cheng KC, Guo Z, Tong X, Saksena AK, Girijavallabhan V, Njoroge FG. Bogen SL, et al. Among authors: tong x. J Med Chem. 2009 Jun 25;52(12):3679-88. doi: 10.1021/jm801632a. J Med Chem. 2009. PMID: 19456105
Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.
Venkatraman S, Blackman M, Wu W, Nair L, Arasappan A, Padilla A, Bogen S, Bennett F, Chen K, Pichardo J, Tong X, Prongay A, Cheng KC, Girijavallabhan V, George Njoroge F. Venkatraman S, et al. Among authors: tong x. Bioorg Med Chem. 2009 Jul 1;17(13):4486-95. doi: 10.1016/j.bmc.2009.05.012. Epub 2009 May 9. Bioorg Med Chem. 2009. PMID: 19481946
Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.
Velázquez F, Sannigrahi M, Bennett F, Lovey RG, Arasappan A, Bogen S, Nair L, Venkatraman S, Blackman M, Hendrata S, Huang Y, Huelgas R, Pinto P, Cheng KC, Tong X, McPhail AT, Njoroge FG. Velázquez F, et al. Among authors: tong x. J Med Chem. 2010 Apr 22;53(8):3075-85. doi: 10.1021/jm9016027. J Med Chem. 2010. PMID: 20302300
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bennett F, Huang Y, Hendrata S, Lovey R, Bogen SL, Pan W, Guo Z, Prongay A, Chen KX, Arasappan A, Venkatraman S, Velazquez F, Nair L, Sannigrahi M, Tong X, Pichardo J, Cheng KC, Girijavallabhan VM, Saksena AK, Njoroge FG. Bennett F, et al. Among authors: tong x. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2617-21. doi: 10.1016/j.bmcl.2010.02.063. Epub 2010 Feb 19. Bioorg Med Chem Lett. 2010. PMID: 20303756
5,310 results