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Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.
Liu T, Nair SJ, Lescarbeau A, Belani J, Peluso S, Conley J, Tillotson B, O'Hearn P, Smith S, Slocum K, West K, Helble J, Douglas M, Bahadoor A, Ali J, McGovern K, Fritz C, Palombella VJ, Wylie A, Castro AC, Tremblay MR. Liu T, et al. J Med Chem. 2012 Oct 25;55(20):8859-78. doi: 10.1021/jm3011542. Epub 2012 Oct 12. J Med Chem. 2012. PMID: 23025805
Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)-γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate.
Evans CA, Liu T, Lescarbeau A, Nair SJ, Grenier L, Pradeilles JA, Glenadel Q, Tibbitts T, Rowley AM, DiNitto JP, Brophy EE, O'Hearn EL, Ali JA, Winkler DG, Goldstein SI, O'Hearn P, Martin CM, Hoyt JG, Soglia JR, Cheung C, Pink MM, Proctor JL, Palombella VJ, Tremblay MR, Castro AC. Evans CA, et al. Among authors: liu t. ACS Med Chem Lett. 2016 Jul 22;7(9):862-7. doi: 10.1021/acsmedchemlett.6b00238. eCollection 2016 Sep 8. ACS Med Chem Lett. 2016. PMID: 27660692 Free PMC article.
Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy.
Faridoon, Zheng J, Zhang T, Tong S, Liu T, Cui J, Xu H, Hu D, Shen Y, Yin Y, Zhao D, Tan C, Dong X, Chen J, Ji F, Tong C, Li JJ, Li J, Zhang G. Faridoon, et al. Among authors: liu t. J Med Chem. 2024 Jun 13;67(11):9431-9446. doi: 10.1021/acs.jmedchem.4c00552. Epub 2024 May 31. J Med Chem. 2024. PMID: 38818879
Analgetic activity of cyclized basic anilides.
Havera HJ, VanDyke JW Jr, Liu TM, Sancilio LF. Havera HJ, et al. Among authors: liu tm. J Med Chem. 1969 Jul;12(4):580-3. doi: 10.1021/jm00304a004. J Med Chem. 1969. PMID: 5793144 No abstract available.
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