Portoghese PS - Search Results

1

Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys.

Yekkirala AS, Banks ML, Lunzer MM, Negus SS, Rice KC, Portoghese PS. Yekkirala AS, et al. Among authors: portoghese ps. ACS Chem Neurosci. 2012 Sep 19;3(9):720-7. doi: 10.1021/cn300049m. Epub 2012 Jul 5. ACS Chem Neurosci. 2012. PMID: 23019498 Free PMC article.

2

Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.

Lunzer MM, Yekkirala A, Hebbel RP, Portoghese PS. Lunzer MM, et al. Among authors: portoghese ps. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):6061-5. doi: 10.1073/pnas.0700295104. Epub 2007 Mar 26. Proc Natl Acad Sci U S A. 2007. PMID: 17389363 Free PMC article.

3

Selectivity of delta- and kappa-opioid ligands depends on the route of central administration in mice.

Lunzer MM, Portoghese PS. Lunzer MM, et al. Among authors: portoghese ps. J Pharmacol Exp Ther. 2007 Jul;322(1):166-71. doi: 10.1124/jpet.107.120279. Epub 2007 Mar 30. J Pharmacol Exp Ther. 2007. PMID: 17400888

4

A bivalent ligand (KMN-21) antagonist for mu/kappa heterodimeric opioid receptors.

Zhang S, Yekkirala A, Tang Y, Portoghese PS. Zhang S, et al. Among authors: portoghese ps. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6978-80. doi: 10.1016/j.bmcl.2009.10.045. Epub 2009 Nov 4. Bioorg Med Chem Lett. 2009. PMID: 19892550 Free PMC article.

5

N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers.

Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS. Yekkirala AS, et al. Among authors: portoghese ps. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5098-103. doi: 10.1073/pnas.1016277108. Epub 2011 Mar 8. Proc Natl Acad Sci U S A. 2011. PMID: 21385944 Free PMC article.

6

Opioid activity of spinally selective analogues of N-naphthoyl-β-naltrexamine in HEK-293 cells and mice.

Le Naour M, Lunzer MM, Powers MD, Portoghese PS. Le Naour M, et al. Among authors: portoghese ps. J Med Chem. 2012 Jan 26;55(2):670-7. doi: 10.1021/jm200902v. Epub 2012 Jan 5. J Med Chem. 2012. PMID: 22136373 Free PMC article.

7

Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective μ-δ agonists.

Yekkirala AS, Kalyuzhny AE, Portoghese PS. Yekkirala AS, et al. Among authors: portoghese ps. ACS Chem Neurosci. 2010 Feb 17;1(2):146-54. doi: 10.1021/cn9000236. Epub 2009 Nov 25. ACS Chem Neurosci. 2010. PMID: 22816017 Free PMC article.

8

The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors.

Metcalf MD, Yekkirala AS, Powers MD, Kitto KF, Fairbanks CA, Wilcox GL, Portoghese PS. Metcalf MD, et al. Among authors: portoghese ps. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9. doi: 10.1021/cn3000394. Epub 2012 May 22. ACS Chem Neurosci. 2012. PMID: 22860219 Free PMC article.

9

An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands.

Yekkirala AS, Kalyuzhny AE, Portoghese PS. Yekkirala AS, et al. Among authors: portoghese ps. ACS Chem Biol. 2013 Jul 19;8(7):1412-6. doi: 10.1021/cb400113d. Epub 2013 May 17. ACS Chem Biol. 2013. PMID: 23675763 Free PMC article.

10

Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB1) receptors are potent analgesics devoid of tolerance.

Le Naour M, Akgün E, Yekkirala A, Lunzer MM, Powers MD, Kalyuzhny AE, Portoghese PS. Le Naour M, et al. Among authors: portoghese ps. J Med Chem. 2013 Jul 11;56(13):5505-13. doi: 10.1021/jm4005219. Epub 2013 Jun 20. J Med Chem. 2013. PMID: 23734559 Free PMC article.

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