Prysyazhna O - Search Results

1

cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control.

Burgoyne JR, Prysyazhna O, Rudyk O, Eaton P. Burgoyne JR, et al. Among authors: prysyazhna o. Hypertension. 2012 Nov;60(5):1301-8. doi: 10.1161/HYPERTENSIONAHA.112.198754. Epub 2012 Sep 24. Hypertension. 2012. PMID: 23006734

2

Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension.

Prysyazhna O, Rudyk O, Eaton P. Prysyazhna O, et al. Nat Med. 2012 Jan 15;18(2):286-90. doi: 10.1038/nm.2603. Nat Med. 2012. PMID: 22245782 Free PMC article.

3

Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse.

Rudyk O, Prysyazhna O, Burgoyne JR, Eaton P. Rudyk O, et al. Among authors: prysyazhna o. Circulation. 2012 Jul 17;126(3):287-95. doi: 10.1161/CIRCULATIONAHA.112.101287. Epub 2012 Jun 9. Circulation. 2012. PMID: 22685118 Free PMC article.

4

Protein kinase G oxidation is a major cause of injury during sepsis.

Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar RM, Eaton P. Rudyk O, et al. Among authors: prysyazhna o. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9909-13. doi: 10.1073/pnas.1301026110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716652 Free PMC article.

5

Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide.

Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P. Stubbert D, et al. Among authors: prysyazhna o. Hypertension. 2014 Dec;64(6):1344-51. doi: 10.1161/HYPERTENSIONAHA.114.04281. Epub 2014 Sep 29. Hypertension. 2014. PMID: 25267801

6

Redox regulation of cGMP-dependent protein kinase Iα in the cardiovascular system.

Prysyazhna O, Eaton P. Prysyazhna O, et al. Front Pharmacol. 2015 Jul 17;6:139. doi: 10.3389/fphar.2015.00139. eCollection 2015. Front Pharmacol. 2015. PMID: 26236235 Free PMC article. Review.

7

Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation.

Akashi S, Ahmed KA, Sawa T, Ono K, Tsutsuki H, Burgoyne JR, Ida T, Horio E, Prysyazhna O, Oike Y, Rahaman MM, Eaton P, Fujii S, Akaike T. Akashi S, et al. Among authors: prysyazhna o. Biochemistry. 2016 Feb 9;55(5):751-61. doi: 10.1021/acs.biochem.5b00774. Epub 2016 Jan 29. Biochemistry. 2016. PMID: 26784639

8

Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation.

Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P. Prysyazhna O, et al. J Biol Chem. 2016 Aug 12;291(33):17427-36. doi: 10.1074/jbc.M116.724070. Epub 2016 Jun 24. J Biol Chem. 2016. PMID: 27342776 Free PMC article.

9

Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα).

Burgoyne JR, Prysyazhna O, Richards DA, Eaton P. Burgoyne JR, et al. Among authors: prysyazhna o. Hypertension. 2017 Sep;70(3):577-586. doi: 10.1161/HYPERTENSIONAHA.117.09670. Epub 2017 Jul 17. Hypertension. 2017. PMID: 28716990 Free PMC article.

10

PKG1α oxidation negatively regulates food seeking behaviour and reward.

Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J, Eaton P. Duraffourd C, et al. Among authors: prysyazhna o. Redox Biol. 2019 Feb;21:101077. doi: 10.1016/j.redox.2018.101077. Epub 2018 Dec 18. Redox Biol. 2019. PMID: 30593979 Free PMC article.

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