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Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf>MEK>ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK.
Sambade MJ, Camp JT, Kimple RJ, Sartor CI, Shields JM. Sambade MJ, et al. Among authors: kimple rj. Radiother Oncol. 2009 Dec;93(3):639-44. doi: 10.1016/j.radonc.2009.09.006. Epub 2009 Oct 23. Radiother Oncol. 2009. PMID: 19853943 Free PMC article.
Cosmetic outcomes for accelerated partial breast irradiation before surgical excision of early-stage breast cancer using single-dose intraoperative radiotherapy.
Kimple RJ, Klauber-DeMore N, Kuzmiak CM, Pavic D, Lian J, Livasy CA, Esler L, Moore DT, Sartor CI, Ollila DW. Kimple RJ, et al. Int J Radiat Oncol Biol Phys. 2011 Feb 1;79(2):400-7. doi: 10.1016/j.ijrobp.2009.10.032. Epub 2010 Apr 13. Int J Radiat Oncol Biol Phys. 2011. PMID: 20395062 Free PMC article. Clinical Trial.
Phase 2 study of pre-excision single-dose intraoperative radiation therapy for early-stage breast cancers: six-year update with application of the ASTRO accelerated partial breast irradiation consensus statement criteria.
Vanderwalde NA, Jones EL, Kimple RJ, Moore DT, Klauber-Demore N, Sartor CI, Ollila DW. Vanderwalde NA, et al. Among authors: kimple rj. Cancer. 2013 May 1;119(9):1736-43. doi: 10.1002/cncr.27915. Epub 2013 Jan 29. Cancer. 2013. PMID: 23361892 Free PMC article. Clinical Trial.
168 results