Couture JF - Search Results

1

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.

Senisterra G, Wu H, Allali-Hassani A, Wasney GA, Barsyte-Lovejoy D, Dombrovski L, Dong A, Nguyen KT, Smil D, Bolshan Y, Hajian T, He H, Seitova A, Chau I, Li F, Poda G, Couture JF, Brown PJ, Al-Awar R, Schapira M, Arrowsmith CH, Vedadi M. Senisterra G, et al. Among authors: couture jf. Biochem J. 2013 Jan 1;449(1):151-9. doi: 10.1042/BJ20121280. Biochem J. 2013. PMID: 22989411 Free PMC article.

2

Molecular basis for the methylation specificity of ATXR5 for histone H3.

Bergamin E, Sarvan S, Malette J, Eram MS, Yeung S, Mongeon V, Joshi M, Brunzelle JS, Michaels SD, Blais A, Vedadi M, Couture JF. Bergamin E, et al. Among authors: couture jf. Nucleic Acids Res. 2017 Jun 20;45(11):6375-6387. doi: 10.1093/nar/gkx224. Nucleic Acids Res. 2017. PMID: 28383693 Free PMC article.

3

Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic.

Avdic V, Zhang P, Lanouette S, Voronova A, Skerjanc I, Couture JF. Avdic V, et al. Among authors: couture jf. FASEB J. 2011 Mar;25(3):960-7. doi: 10.1096/fj.10-171959. Epub 2010 Dec 6. FASEB J. 2011. PMID: 21135039

4

Structural and biochemical insights into MLL1 core complex assembly.

Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF. Avdic V, et al. Among authors: couture jf. Structure. 2011 Jan 12;19(1):101-8. doi: 10.1016/j.str.2010.09.022. Structure. 2011. PMID: 21220120 Free article.

5

Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.

Sarvan S, Avdic V, Tremblay V, Chaturvedi CP, Zhang P, Lanouette S, Blais A, Brunzelle JS, Brand M, Couture JF. Sarvan S, et al. Among authors: couture jf. Nat Struct Mol Biol. 2011 Jun 5;18(7):857-9. doi: 10.1038/nsmb.2093. Nat Struct Mol Biol. 2011. PMID: 21642971 Free PMC article.

6

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

Zhang P, Lee H, Brunzelle JS, Couture JF. Zhang P, et al. Among authors: couture jf. Nucleic Acids Res. 2012 May;40(9):4237-46. doi: 10.1093/nar/gkr1235. Epub 2012 Jan 20. Nucleic Acids Res. 2012. PMID: 22266653 Free PMC article.

7

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.

Zhang P, Chaturvedi CP, Tremblay V, Cramet M, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF. Zhang P, et al. Among authors: couture jf. Genes Dev. 2015 Jan 15;29(2):123-8. doi: 10.1101/gad.254870.114. Genes Dev. 2015. PMID: 25593305 Free PMC article.

8

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.

Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G. Qu Q, et al. Among authors: couture jf. Cell. 2018 Aug 23;174(5):1117-1126.e12. doi: 10.1016/j.cell.2018.07.020. Epub 2018 Aug 9. Cell. 2018. PMID: 30100186 Free PMC article.

9

A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS.

Yang Y, Joshi M, Takahashi YH, Ning Z, Qu Q, Brunzelle JS, Skiniotis G, Figeys D, Shilatifard A, Couture JF. Yang Y, et al. Among authors: couture jf. Nucleic Acids Res. 2020 Jan 10;48(1):421-431. doi: 10.1093/nar/gkz1037. Nucleic Acids Res. 2020. PMID: 31724694 Free PMC article.

10

Molecular recognition of histone H3 by the WD40 protein WDR5.

Couture JF, Collazo E, Trievel RC. Couture JF, et al. Nat Struct Mol Biol. 2006 Aug;13(8):698-703. doi: 10.1038/nsmb1116. Epub 2006 Jul 9. Nat Struct Mol Biol. 2006. PMID: 16829960

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