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Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Ha BH, et al. Among authors: krauthammer m. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16107-12. doi: 10.1073/pnas.1214447109. Epub 2012 Sep 17. Proc Natl Acad Sci U S A. 2012. PMID: 22988085 Free PMC article.
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R. Krauthammer M, et al. Nat Genet. 2012 Sep;44(9):1006-14. doi: 10.1038/ng.2359. Epub 2012 Jul 29. Nat Genet. 2012. PMID: 22842228 Free PMC article.
Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors.
Choi J, Landrette SF, Wang T, Evans P, Bacchiocchi A, Bjornson R, Cheng E, Stiegler AL, Gathiaka S, Acevedo O, Boggon TJ, Krauthammer M, Halaban R, Xu T. Choi J, et al. Among authors: krauthammer m. Pigment Cell Melanoma Res. 2014 Mar;27(2):253-62. doi: 10.1111/pcmr.12197. Epub 2014 Jan 6. Pigment Cell Melanoma Res. 2014. PMID: 24283590 Free PMC article.
RASopathy Gene Mutations in Melanoma.
Halaban R, Krauthammer M. Halaban R, et al. Among authors: krauthammer m. J Invest Dermatol. 2016 Sep;136(9):1755-1759. doi: 10.1016/j.jid.2016.05.095. Epub 2016 May 25. J Invest Dermatol. 2016. PMID: 27236105 Free PMC article. Review.
Rare SF3B1 R625 mutations in cutaneous melanoma.
Kong Y, Krauthammer M, Halaban R. Kong Y, et al. Among authors: krauthammer m. Melanoma Res. 2014 Aug;24(4):332-4. doi: 10.1097/CMR.0000000000000071. Melanoma Res. 2014. PMID: 24709888 Free PMC article.
PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.
Halaban R, Zhang W, Bacchiocchi A, Cheng E, Parisi F, Ariyan S, Krauthammer M, McCusker JP, Kluger Y, Sznol M. Halaban R, et al. Among authors: krauthammer m. Pigment Cell Melanoma Res. 2010 Apr;23(2):190-200. doi: 10.1111/j.1755-148X.2010.00685.x. Epub 2010 Feb 10. Pigment Cell Melanoma Res. 2010. PMID: 20149136 Free PMC article.
Phosphoproteomic screen identifies potential therapeutic targets in melanoma.
Tworkoski K, Singhal G, Szpakowski S, Zito CI, Bacchiocchi A, Muthusamy V, Bosenberg M, Krauthammer M, Halaban R, Stern DF. Tworkoski K, et al. Among authors: krauthammer m. Mol Cancer Res. 2011 Jun;9(6):801-12. doi: 10.1158/1541-7786.MCR-10-0512. Epub 2011 Apr 26. Mol Cancer Res. 2011. PMID: 21521745 Free PMC article.
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Krauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R. Krauthammer M, et al. Nat Genet. 2015 Sep;47(9):996-1002. doi: 10.1038/ng.3361. Epub 2015 Jul 27. Nat Genet. 2015. PMID: 26214590 Free PMC article.
127 results