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Page 1
Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1.
Orrling KM, Jansen C, Vu XL, Balmer V, Bregy P, Shanmugham A, England P, Bailey D, Cos P, Maes L, Adams E, van den Bogaart E, Chatelain E, Ioset JR, van de Stolpe A, Zorg S, Veerman J, Seebeck T, Sterk GJ, de Esch IJ, Leurs R. Orrling KM, et al. Among authors: cos p. J Med Chem. 2012 Oct 25;55(20):8745-56. doi: 10.1021/jm301059b. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22963052
Challenges and pitfalls in antioxidant research.
Hermans N, Cos P, Maes L, De Bruyne T, Vanden Berghe D, Vlietinck AJ, Pieters L. Hermans N, et al. Among authors: cos p. Curr Med Chem. 2007;14(4):417-30. doi: 10.2174/092986707779941005. Curr Med Chem. 2007. PMID: 17305543 Review.
Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues.
Van Baelen G, Hostyn S, Dhooghe L, Tapolcsányi P, Mátyus P, Lemière G, Dommisse R, Kaiser M, Brun R, Cos P, Maes L, Hajós G, Riedl Z, Nagy I, Maes BU, Pieters L. Van Baelen G, et al. Among authors: cos p. Bioorg Med Chem. 2009 Oct 15;17(20):7209-17. doi: 10.1016/j.bmc.2009.08.057. Epub 2009 Sep 3. Bioorg Med Chem. 2009. PMID: 19781948
Design and evaluation of Trypanosoma brucei metacaspase inhibitors.
Berg M, Van der Veken P, Joossens J, Muthusamy V, Breugelmans M, Moss CX, Rudolf J, Cos P, Coombs GH, Maes L, Haemers A, Mottram JC, Augustyns K. Berg M, et al. Among authors: cos p. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2001-6. doi: 10.1016/j.bmcl.2010.01.099. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20167486 Free PMC article.
Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis.
Berg M, Kohl L, Van der Veken P, Joossens J, Al-Salabi MI, Castagna V, Giannese F, Cos P, Versées W, Steyaert J, Grellier P, Haemers A, Degano M, Maes L, de Koning HP, Augustyns K. Berg M, et al. Among authors: cos p. Antimicrob Agents Chemother. 2010 May;54(5):1900-8. doi: 10.1128/AAC.01787-09. Epub 2010 Mar 1. Antimicrob Agents Chemother. 2010. PMID: 20194690 Free PMC article.
Drug to genome to drug: discovery of new antiplasmodial compounds.
Beghyn TB, Charton J, Leroux F, Laconde G, Bourin A, Cos P, Maes L, Deprez B. Beghyn TB, et al. Among authors: cos p. J Med Chem. 2011 May 12;54(9):3222-40. doi: 10.1021/jm1014617. Epub 2011 Apr 19. J Med Chem. 2011. PMID: 21504142
267 results