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Diesterified nitrone rescues nitroso-redox levels and increases myocyte contraction via increased SR Ca(2+) handling.
Traynham CJ, Roof SR, Wang H, Prosak RA, Tang L, Viatchenko-Karpinski S, Ho HT, Racoma IO, Catalano DJ, Huang X, Han Y, Kim SU, Gyorke S, Billman GE, Villamena FA, Ziolo MT. Traynham CJ, et al. Among authors: roof sr. PLoS One. 2012;7(12):e52005. doi: 10.1371/journal.pone.0052005. Epub 2012 Dec 27. PLoS One. 2012. PMID: 23300588 Free PMC article.
Nitric oxide-dependent activation of CaMKII increases diastolic sarcoplasmic reticulum calcium release in cardiac myocytes in response to adrenergic stimulation.
Curran J, Tang L, Roof SR, Velmurugan S, Millard A, Shonts S, Wang H, Santiago D, Ahmad U, Perryman M, Bers DM, Mohler PJ, Ziolo MT, Shannon TR. Curran J, et al. Among authors: roof sr. PLoS One. 2014 Feb 3;9(2):e87495. doi: 10.1371/journal.pone.0087495. eCollection 2014. PLoS One. 2014. PMID: 24498331 Free PMC article.
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease.
Shettigar V, Zhang B, Little SC, Salhi HE, Hansen BJ, Li N, Zhang J, Roof SR, Ho HT, Brunello L, Lerch JK, Weisleder N, Fedorov VV, Accornero F, Rafael-Fortney JA, Gyorke S, Janssen PM, Biesiadecki BJ, Ziolo MT, Davis JP. Shettigar V, et al. Among authors: roof sr. Nat Commun. 2016 Feb 24;7:10794. doi: 10.1038/ncomms10794. Nat Commun. 2016. PMID: 26908229 Free PMC article.
NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model.
Peterson JM, Wang DJ, Shettigar V, Roof SR, Canan BD, Bakkar N, Shintaku J, Gu JM, Little SC, Ratnam NM, Londhe P, Lu L, Gaw CE, Petrosino JM, Liyanarachchi S, Wang H, Janssen PML, Davis JP, Ziolo MT, Sharma SM, Guttridge DC. Peterson JM, et al. Among authors: roof sr. Nat Commun. 2018 Aug 24;9(1):3431. doi: 10.1038/s41467-018-05910-1. Nat Commun. 2018. PMID: 30143619 Free PMC article.
17 results