de Esch IJ - Search Results

1

Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain.

Akdemir A, Edink E, Thompson AJ, Lummis SC, Kooistra AJ, de Graaf C, de Esch IJ. Akdemir A, et al. Among authors: de esch ij, de graaf c. Bioorg Med Chem. 2012 Oct 1;20(19):5992-6002. doi: 10.1016/j.bmc.2012.06.054. Epub 2012 Jul 11. Bioorg Med Chem. 2012. PMID: 22959526 Free PMC article.

2

Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.

Terzioglu N, van Rijn RM, Bakker RA, De Esch IJ, Leurs R. Terzioglu N, et al. Among authors: de esch ij. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5251-6. doi: 10.1016/j.bmcl.2004.08.035. Bioorg Med Chem Lett. 2004. PMID: 15454206

3

The role and application of in silico docking in chemical genomics research.

Jongejan A, de Graaf C, Vermeulen NP, Leurs R, de Esch IJ. Jongejan A, et al. Among authors: de esch ij, de graaf c. Methods Mol Biol. 2005;310:63-91. doi: 10.1007/978-1-59259-948-6_5. Methods Mol Biol. 2005. PMID: 16350947

4

Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo.

Smits RA, Lim HD, Hanzer A, Zuiderveld OP, Guaita E, Adami M, Coruzzi G, Leurs R, de Esch IJ. Smits RA, et al. Among authors: de esch ij. J Med Chem. 2008 Apr 24;51(8):2457-67. doi: 10.1021/jm7014217. Epub 2008 Mar 22. J Med Chem. 2008. PMID: 18357976

5

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

Ulens C, Akdemir A, Jongejan A, van Elk R, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D, de Esch IJ. Ulens C, et al. Among authors: de esch ij. J Med Chem. 2009 Apr 23;52(8):2372-83. doi: 10.1021/jm801400g. J Med Chem. 2009. PMID: 19331415

6

Molecular determinants of ligand binding to H4R species variants.

Lim HD, de Graaf C, Jiang W, Sadek P, McGovern PM, Istyastono EP, Bakker RA, de Esch IJ, Thurmond RL, Leurs R. Lim HD, et al. Among authors: de esch ij, de graaf c. Mol Pharmacol. 2010 May;77(5):734-43. doi: 10.1124/mol.109.063040. Epub 2010 Jan 26. Mol Pharmacol. 2010. PMID: 20103609

7

Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.

de Kloe GE, Retra K, Geitmann M, Källblad P, Nahar T, van Elk R, Smit AB, van Muijlwijk-Koezen JE, Leurs R, Irth H, Danielson UH, de Esch IJ. de Kloe GE, et al. Among authors: de esch ij. J Med Chem. 2010 Oct 14;53(19):7192-201. doi: 10.1021/jm100834y. J Med Chem. 2010. PMID: 20828128

8

An efficient and information-rich biochemical method design for fragment library screening on ion channels.

Thompson AJ, Verheij MH, Leurs R, De Esch IJ, Lummis SC. Thompson AJ, et al. Among authors: de esch ij. Biotechniques. 2010 Nov;49(5):822-9. doi: 10.2144/000113538. Biotechniques. 2010. PMID: 21091447 Free article.

9

Molecular determinants of selective agonist and antagonist binding to the histamine H₄ receptor.

Istyastono EP, de Graaf C, de Esch IJ, Leurs R. Istyastono EP, et al. Among authors: de esch ij, de graaf c. Curr Top Med Chem. 2011;11(6):661-79. doi: 10.2174/1568026611109060661. Curr Top Med Chem. 2011. PMID: 21261593 Review.

10

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis.

Edink E, Rucktooa P, Retra K, Akdemir A, Nahar T, Zuiderveld O, van Elk R, Janssen E, van Nierop P, van Muijlwijk-Koezen J, Smit AB, Sixma TK, Leurs R, de Esch IJ. Edink E, et al. Among authors: de esch ij. J Am Chem Soc. 2011 Apr 13;133(14):5363-71. doi: 10.1021/ja110571r. Epub 2011 Feb 15. J Am Chem Soc. 2011. PMID: 21322593

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