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Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC.
Strell C, Norberg KJ, Mezheyeuski A, Schnittert J, Kuninty PR, Moro CF, Paulsson J, Schultz NA, Calatayud D, Löhr JM, Frings O, Verbeke CS, Heuchel RL, Prakash J, Johansen JS, Östman A. Strell C, et al. Among authors: ostman a. Br J Cancer. 2017 Jun 27;117(1):65-77. doi: 10.1038/bjc.2017.140. Epub 2017 May 18. Br J Cancer. 2017. PMID: 28524160 Free PMC article.
Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer.
Schnittert J, Bansal R, Mardhian DF, van Baarlen J, Östman A, Prakash J. Schnittert J, et al. Among authors: ostman a. FASEB J. 2019 May;33(5):6609-6621. doi: 10.1096/fj.201802336R. Epub 2019 Feb 26. FASEB J. 2019. PMID: 30808244
In summary, this study presents ITGA11 as an interesting stromal therapeutic target that plays a crucial role in the regulation of the differentiation of PSCs into CAFs and paracrine effects.-Schnittert, J., Bansal, R., Mardhian, D. F., van Baarlen, J., Ostman, A …
In summary, this study presents ITGA11 as an interesting stromal therapeutic target that plays a crucial role in the regulation of th …
ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer.
Kuninty PR, Bansal R, De Geus SWL, Mardhian DF, Schnittert J, van Baarlen J, Storm G, Bijlsma MF, van Laarhoven HW, Metselaar JM, Kuppen PJK, Vahrmeijer AL, Östman A, Sier CFM, Prakash J. Kuninty PR, et al. Among authors: ostman a. Sci Adv. 2019 Sep 4;5(9):eaax2770. doi: 10.1126/sciadv.aax2770. eCollection 2019 Sep. Sci Adv. 2019. PMID: 31517053 Free PMC article.
Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase.
Persson C, Sävenhed C, Bourdeau A, Tremblay ML, Markova B, Böhmer FD, Haj FG, Neel BG, Elson A, Heldin CH, Rönnstrand L, Ostman A, Hellberg C. Persson C, et al. Among authors: ostman a. Mol Cell Biol. 2004 Mar;24(5):2190-201. doi: 10.1128/MCB.24.5.2190-2201.2004. Mol Cell Biol. 2004. PMID: 14966296 Free PMC article.
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.
Furuhashi M, Sjöblom T, Abramsson A, Ellingsen J, Micke P, Li H, Bergsten-Folestad E, Eriksson U, Heuchel R, Betsholtz C, Heldin CH, Ostman A. Furuhashi M, et al. Among authors: ostman a. Cancer Res. 2004 Apr 15;64(8):2725-33. doi: 10.1158/0008-5472.can-03-1489. Cancer Res. 2004. PMID: 15087386
233 results